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FLNA [cytosol]
Stable Identifier
R-HSA-210019
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Filamin-A
Locations in the PathwayBrowser for interactor UniProt:P05556%20ITGB1
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GP1b-IX-V activation signalling (Homo sapiens)
GP1b-IX-V binds filamin (Homo sapiens)
FLNA [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
OAS antiviral response (Homo sapiens)
RNASEL binds 2'-5' oligoadenylate (Homo sapiens)
FLNA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21333 FLNA
Gene Names
FLNA, FLN, FLN1
Chain
initiator methionine:, chain:2-2647
Reference Genes
BioGPS Gene:2316 FLNA
COSMIC (genes):FLNA FLNA
CTD Gene:2316 FLNA
dbSNP Gene:2316 FLNA
ENSEMBL:ENSG00000196924 FLNA
ENSEMBL_homo_sapiens_GENE:ENSG00000196924.19 FLNA
HGNC:3754 FLNA
KEGG Gene (Homo sapiens):2316 FLNA
Monarch:2316 FLNA
NCBI Gene:2316 FLNA
OMIM:300017 FLNA
UCSC:P21333 FLNA
Reference Transcript
RefSeq:NM_001456.3 FLNA
RefSeq:NM_001110556.1 FLNA
Other Identifiers
11715425_x_at
11746880_x_at
11752142_a_at
17115505
200859_PM_x_at
200859_x_at
213746_PM_s_at
213746_s_at
214752_PM_x_at
214752_x_at
2316
32749_s_at
32750_r_at
4027177
4027178
4027179
4027180
4027182
4027185
4027189
4027190
4027192
4027194
4027196
4027198
4027199
4027201
4027202
4027203
4027205
4027207
4027208
4027209
4027210
4027215
4027216
4027217
4027220
4027221
4027223
4027225
4027226
4027227
4027229
4027230
4027231
4027232
4027233
4027235
4027236
4027238
4027239
4027241
4027242
4027243
4027244
4027245
4027246
4027247
4027248
4027250
4027252
4027256
4027257
4027259
75220_s_at
8176026
89945_s_at
A_33_P3366120
A_33_P3408711
GE61113
GO:0000278
GO:0001525
GO:0001664
GO:0001837
GO:0001974
GO:0003007
GO:0003012
GO:0003013
GO:0003723
GO:0003779
GO:0005080
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005730
GO:0005737
GO:0005794
GO:0005802
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005903
GO:0005911
GO:0005925
GO:0005938
GO:0006351
GO:0006355
GO:0006886
GO:0006913
GO:0007010
GO:0007059
GO:0007155
GO:0007195
GO:0007597
GO:0008092
GO:0010572
GO:0010977
GO:0012501
GO:0015459
GO:0015629
GO:0016020
GO:0016071
GO:0016192
GO:0016479
GO:0019900
GO:0021943
GO:0021987
GO:0022414
GO:0023052
GO:0030018
GO:0030030
GO:0030036
GO:0030154
GO:0030163
GO:0030334
GO:0030426
GO:0030863
GO:0031267
GO:0031523
GO:0032231
GO:0032233
GO:0032432
GO:0034330
GO:0034394
GO:0034988
GO:0035855
GO:0036211
GO:0042060
GO:0042177
GO:0042307
GO:0042789
GO:0042803
GO:0042995
GO:0043025
GO:0043066
GO:0043113
GO:0043123
GO:0043198
GO:0043204
GO:0043226
GO:0043232
GO:0043433
GO:0044295
GO:0044319
GO:0044325
GO:0044782
GO:0044877
GO:0045022
GO:0045184
GO:0045216
GO:0045296
GO:0046332
GO:0048471
GO:0048680
GO:0048856
GO:0048870
GO:0050808
GO:0050821
GO:0051015
GO:0051020
GO:0051209
GO:0051220
GO:0051604
GO:0051764
GO:0055065
GO:0055085
GO:0060271
GO:0070062
GO:0070527
GO:0071526
GO:0072659
GO:0090042
GO:0090307
GO:0097368
GO:0097440
GO:0098772
GO:0098794
GO:0098978
GO:0140014
GO:0140297
GO:1900026
GO:1901381
GO:1902396
GO:1905000
GO:1905031
GO:1990779
GO:2000179
GO:2001046
GO:2001224
HMNXSV003030321
Hs.195464.1.A1_3p_a_at
ILMN_1687335
PH_hs_0011552
TC0X001530.hg
X53416_at
Participates
as a member of
Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
Filamin [cytosol] (Homo sapiens)
as a component of
GPIb-IX-V:vWF:filamin-A [plasma membrane] (Homo sapiens)
RNASEL:FLNA [cytosol] (Homo sapiens)
FLNA [cytosol] (Homo sapiens)
as an input of
GP1b-IX-V binds filamin (Homo sapiens)
as an output of
RNASEL binds 2'-5' oligoadenylate (Homo sapiens)
Other forms of this molecule
FLNA [extracellular region]
p-S2152-FLNA [cytosol]
Inferred To
cher [cytosol]
(Drosophila melanogaster)
fln-1 [cytosol]
(Caenorhabditis elegans)
Flna [cytosol]
(Mus musculus)
Flna [cytosol]
(Rattus norvegicus)
FLNA [cytosol]
(Bos taurus)
FLNA [cytosol]
(Canis familiaris)
FLNA [cytosol]
(Sus scrofa)
abpC [cytosol]
(Dictyostelium discoideum)
flna [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001447.2
,
NP_001104026.1
OpenTargets
ENSG00000196924
GeneCards
P21333
HPA
ENSG00000196924-FLNA
Ensembl
ENST00000369850
,
ENSP00000353467
,
ENSP00000358866
,
ENSG00000196924
,
ENST00000360319
PRO
P21333
Pharos - Targets
P21333
Orphanet
16058
PDB
2BP3
,
2K7Q
,
2BRQ
,
2JF1
,
2W0P
,
2K3T
,
2K7P
,
7SC4
,
7SFT
,
3ISW
,
3HOC
,
6D8C
,
3HOR
,
3CNK
,
4P3W
,
2J3S
,
5XR1
,
2WFN
,
2AAV
,
2MTP
,
4M9P
,
3HOP
,
3RGH
,
6EW1
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05556 ITGB1
2
ITGB1 [endosome membrane]
(R-HSA-9611157)
ITGB1 [plasma membrane]
(R-HSA-57596)
0.819
6
UniProt:P26010 ITGB7
1
ITGB7 [plasma membrane]
(R-HSA-3006427)
0.737
7
UniProt:O95067 CCNB2
1
CCNB2 [cytosol]
(R-HSA-68897)
0.679
8
UniProt:Q8N264 ARHGAP24
1
ARHGAP24 [cytosol]
(R-HSA-2976578)
0.639
6
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.615
3
UniProt:P05106 ITGB3
3
p-T779-ITGB3 [plasma membrane]
(R-HSA-432107)
ITGB3(27-?) [platelet alpha granule membrane]
(R-HSA-114512)
ITGB3 [plasma membrane]
(R-HSA-57600)
0.611
3
UniProt:P08514-1 ITGA2B
0.611
3
UniProt:Q12948 FOXC1
1
FOXC1 [nucleoplasm]
(R-HSA-3927815)
0.61
8
UniProt:P35372 OPRM1
1
OPRM1 [plasma membrane]
(R-HSA-60951)
0.602
5
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.597
3
UniProt:Q86SQ0 PHLB2
0.564
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.564
2
UniProt:P26010-1 ITGB7
0.558
2
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.558
2
UniProt:P26583 HMGB2
1
HMGB2 [nucleoplasm]
(R-HSA-266211)
0.547
2
UniProt:P49286 MTNR1B
1
MTNR1B [plasma membrane]
(R-HSA-419349)
0.547
2
UniProt:O75369 FLNB
1
FLNB [cytosol]
(R-HSA-354163)
0.543
5
UniProt:Q99759 MAP3K3
1
MAP3K3 [cytosol]
(R-HSA-507725)
0.536
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.536
3
UniProt:P07228 ITGB1
1
Integrin beta-1 [plasma membrane]
(R-GGA-2467444)
0.527
2
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.508
2
UniProt:P49768 PSEN1
6
PSEN1(1-467) [plasma membrane]
(R-HSA-201606)
PSEN1(299-467) [azurophil granule membrane]
(R-HSA-6799234)
PSEN1(1-467) [azurophil granule membrane]
(R-HSA-6799235)
PSEN1(1-298) [azurophil granule membrane]
(R-HSA-6799209)
PSEN1(1-298) [plasma membrane]
(R-HSA-2534298)
PSEN1(299-467) [plasma membrane]
(R-HSA-2534245)
0.508
2
UniProt:P51114 FXR1
2
FXR1(2-784)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802326)
FXR1(2-784)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802530)
0.508
2
UniProt:P49810 PSEN2
2
PSEN2(1-297) [plasma membrane]
(R-HSA-201599)
PSEN2(298-448) [plasma membrane]
(R-HSA-9013329)
0.508
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
14
UniProt:Q9WMX2-PRO_0000037548
0.463
6
UniProt:Q9WMX2-PRO_0000037551
0.463
6
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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