Reactome | Diiodinated tyrosine can be deiodinated

Diiodinated tyrosine can be deiodinated

Stable Identifier

R-HSA-209960

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

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The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).

Literature References

PubMed ID	Title	Journal	Year
16910871	Cloning and Characterization of a Novel Isoform of Iodotyrosine Dehalogenase 1 (DEHAL1) DEHAL1C from Human Thyroid: Comparisons with DEHAL1 and DEHAL1B Gnidehou, S, Lacroix, L, Sezan, A, Ohayon, R, Noel-Hudson, MS, Morand, S, Francon, J, Courtin, F, Virion, A, Dupuy, C	Thyroid	2006