The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).
Noel-Hudson, MS, Courtin, F, Sezan, A, Francon, J, Ohayon, R, Virion, A, Dupuy, C, Morand, S, Lacroix, L, Gnidehou, S
oxidoreductase activity of DEHAL1:FMN [plasma membrane]
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