DIT and MIT combine to form triiodothyronine

Stable Identifier
R-HSA-209925
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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DIT and MIT combine to form triiodothyronine
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Mono- and di-iodinated tyrosine can combine to form tri-iodothyronine (T3). The hormone thyrotropin can stimulate the production of T3 and T4.

Literature References
PubMed ID Title Journal Year
67547 Biosynthesis of thyroid hormone: basic and clinical aspects

Niepomniszcze, H, Degroot, LJ

Metabolism 1977
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peroxidase activity of TPO [plasma membrane]

Physical Entity
TPO [plasma membrane] (Homo sapiens)
Activity
peroxidase activity (GO:0004601)
This event is regulated
Positively by
Regulator
Thyrotropin [extracellular region] (Homo sapiens)
Orthologous Events
DIT and MIT combine to form triiodothyronine (Bos taurus)
DIT and MIT combine to form triiodothyronine (Caenorhabditis elegans)
DIT and MIT combine to form triiodothyronine (Canis familiaris)
DIT and MIT combine to form triiodothyronine (Dictyostelium discoideum)
DIT and MIT combine to form triiodothyronine (Drosophila melanogaster)
DIT and MIT combine to form triiodothyronine (Gallus gallus)
DIT and MIT combine to form triiodothyronine (Mus musculus)
DIT and MIT combine to form triiodothyronine (Rattus norvegicus)
DIT and MIT combine to form triiodothyronine (Sus scrofa)
DIT and MIT combine to form triiodothyronine (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-08)
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