Monoiodinated tyrosine can be deiodinated

Stable Identifier
R-HSA-209921
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human iodotyrosine dehalogenase 1 (DEHAL1) gene is composed of six exons. Two isoforms (DEHAL1 and DEHAL1B) have been published, both of which have a nitroreductase domain and arise from differential splicing in exon 5. The DEHAL1 isoform is a transmembrane protein that catalyzes the NADPH-dependent deiodination of monoiodotyrosine (MIT) and diiodotyrosine (DIT).

Literature References
PubMed ID Title Journal Year
16910871 Cloning and Characterization of a Novel Isoform of Iodotyrosine Dehalogenase 1 (DEHAL1) DEHAL1C from Human Thyroid: Comparisons with DEHAL1 and DEHAL1B

Gnidehou, S, Lacroix, L, Sezan, A, Ohayon, R, Noel-Hudson, MS, Morand, S, Francon, J, Courtin, F, Virion, A, Dupuy, C

Thyroid 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity of DEHAL1:FMN [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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