Reactome | Iodide is taken up by thyroid epithelial cells

Iodide is taken up by thyroid epithelial cells

Stable Identifier

R-HSA-209910

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Iodide is taken up by thyroid epithelial cells

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Iodide (I-) is transported from blood serum into the thyroid cell by the Na+/I- symporter (sodium/iodide). This intrinsic membrane protein uses energy from the inward movement of Na+ to drive the process and accumulate I- in the cell, maintaining a cellular concentration 30-40 times that of the serum concentration. This process, also called the iodide trap, is stimulated by TSH (thyroid stimulating hormone) and is saturable by large amounts of I-.

Literature References

PubMed ID	Title	Journal	Year
8806637	Cloning of the human sodium lodide symporter Jhiang, SM, Mazzaferri, EL, Xing, S, Ryu, K, Furminger, TL, Liu, Q, Smanik, PA	Biochem Biophys Res Commun	1996