Iodide is taken up by thyroid epithelial cells

Stable Identifier
R-HSA-209910
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Iodide (I-) is transported from blood serum into the thyroid cell by the Na+/I- symporter (sodium/iodide). This intrinsic membrane protein uses energy from the inward movement of Na+ to drive the process and accumulate I- in the cell, maintaining a cellular concentration 30-40 times that of the serum concentration. This process, also called the iodide trap, is stimulated by TSH (thyroid stimulating hormone) and is saturable by large amounts of I-.

Literature References
PubMed ID Title Journal Year
8806637 Cloning of the human sodium lodide symporter

Smanik, PA, Liu, Q, Furminger, TL, Ryu, K, Xing, S, Mazzaferri, EL, Jhiang, SM

Biochem Biophys Res Commun 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
iodide transmembrane transporter activity of SLC5A5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created