Reactome | Iodide is taken up by thyroid epithelial cells

Iodide is taken up by thyroid epithelial cells

Stable Identifier

R-HSA-209910

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Iodide is taken up by thyroid epithelial cells

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Iodide (I-) is transported from blood serum into the thyroid cell by the Na+/I- (sodium/iodide) symporter (NIS, SLC5A5) (Smanik et al., 1996). This intrinsic membrane protein uses energy from the inward movement of Na+ to drive the process and accumulate I- in the cell, maintaining a cellular concentration up to 40 times that of the serum concentration. This process, also called the iodide trap, is stimulated by TSH (thyroid stimulating hormone) and is saturable by large amounts of I- (reviewed in Alotaibi et al., 2017; Ravera et al., 2017). The inward movement of Na+ is driven by the charge and Na+ concentration imbalance caused by outwards pumping of Na+ by the Na/K-ATPase. Membrane retention and accumulation of SLC5A5 increases when it is bound to EZR, likely by anchoring it to the cytoskeleton (Faria et al., 2021). Mutations in SLC5A5 are the cause of thyroid dyshormonogenesis 1 (TDH1; MIM:274400) leading to hypothyroidism (reviewed in Ravera et al., 2017).

Literature References

PubMed ID	Title	Journal	Year
8806637	Cloning of the human sodium lodide symporter Smanik, PA, Liu, Q, Furminger, TL, Ryu, K, Xing, S, Mazzaferri, EL, Jhiang, SM	Biochem Biophys Res Commun	1996
28117294	The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation Alotaibi, H, Tuzlakoğlu-Öztürk, M, Tazebay, UH	Mol Imaging Radionucl Ther	2017
28192058	The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications Ravera, S, Reyna-Neyra, A, Ferrandino, G, Amzel, LM, Carrasco, N	Annu Rev Physiol	2017