CYP2R1 25-hydroxylates VD3 to 25(OH)D

Stable Identifier
R-HSA-209845
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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To be functionally active, vitamin D3 (VD3) needs to be dihydroxylated. The first hydroxylation at position 25 is carried out by ER membrane-located vitamin D 25-hydroxylase (CYP2R1) in the liver, forming 25-hydroxyvitamin D (calcidiol, 25(OH)D) (Shinkyo et al. 2004, Cheng et al. 2003).

Literature References
PubMed ID Title Journal Year
12867411 De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase

Cheng, JB, Motola, DL, Mangelsdorf, DJ, Russell, DW

J. Biol. Chem. 2003
15465040 Metabolism of vitamin D by human microsomal CYP2R1

Shinkyo, R, Sakaki, T, Kamakura, M, Ohta, M, Inouye, K

Biochem Biophys Res Commun 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
vitamin D3 25-hydroxylase activity of CYP2R1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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