Reactome | CYP2R1 25-hydroxylates VD3 to 25(OH)D

CYP2R1 25-hydroxylates VD3 to 25(OH)D

Stable Identifier

R-HSA-209845

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Vitamins (Homo sapiens)
        
        CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Vitamin D (calciferol) metabolism (Homo sapiens)
      - CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)

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To be functionally active, vitamin D3 (VD3) needs to be dihydroxylated. The first hydroxylation at position 25 is carried out by ER membrane-located vitamin D 25-hydroxylase (CYP2R1) in the liver, forming 25-hydroxyvitamin D (calcidiol, 25(OH)D) (Shinkyo et al. 2004, Cheng et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
15465040	Metabolism of vitamin D by human microsomal CYP2R1 Shinkyo, R, Ohta, M, Sakaki, T, Kamakura, M, Inouye, K	Biochem Biophys Res Commun	2004
12867411	De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase Mangelsdorf, DJ, Cheng, JB, Russell, DW, Motola, DL	J. Biol. Chem.	2003