Two DITs combine to form thyroxine

Stable Identifier
R-HSA-209840
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Two DITs combine to form thyroxine
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Thyroxine (T4) can be formed by the combination of two diiodotyrosines. The hormone thyrotropin can stimulate the production of T3 and T4.
Literature References
PubMed ID Title Journal Year
67547 Biosynthesis of thyroid hormone: basic and clinical aspects

Niepomniszcze, H, Degroot, LJ

Metabolism 1977
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peroxidase activity of TPO [plasma membrane]

Physical Entity
TPO [plasma membrane] (Homo sapiens)
Activity
peroxidase activity (GO:0004601)
This event is regulated
Positively by
Regulator
Thyrotropin [extracellular region] (Homo sapiens)
Orthologous Events
Two DITs combine to form thyroxine (Bos taurus)
Two DITs combine to form thyroxine (Caenorhabditis elegans)
Two DITs combine to form thyroxine (Canis familiaris)
Two DITs combine to form thyroxine (Dictyostelium discoideum)
Two DITs combine to form thyroxine (Drosophila melanogaster)
Two DITs combine to form thyroxine (Gallus gallus)
Two DITs combine to form thyroxine (Mus musculus)
Two DITs combine to form thyroxine (Rattus norvegicus)
Two DITs combine to form thyroxine (Sus scrofa)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-08)
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