Methylation of N-acetyl-5-HT to form melatonin

Stable Identifier
R-HSA-209821
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Methylation of N-acetyl-5-HT to form melatonin
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Hydroxyindole-O-methyltransferase (HIOMT) catalyzes the last step in the synthesis of melatonin. Melatonin is synthesized and released by the pineal gland and is thought to control circadian rhythms. HIOMT has 3 isoforms and utilizes S-adenosyl-L-methionine (SAM) as the methyl donor in the conversion of N-acetyl-5HT to melatonin.
Literature References
PubMed ID Title Journal Year
7989373 Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters.

Schoen, TJ, Rodriguez, IR, Mazuruk, K, Chader, GJ

J Biol Chem 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

S-methyltransferase activity of ASMT [cytosol]

Physical Entity
ASMT [cytosol] (Homo sapiens)
Activity
S-methyltransferase activity (GO:0008172)
Orthologous Events
Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)
Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)
Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)
Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)
Methylation of N-acetyl-5-HT to form melatonin (Gallus gallus)
Methylation of N-acetyl-5-HT to form melatonin (Mus musculus)
Methylation of N-acetyl-5-HT to form melatonin (Rattus norvegicus)
Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)
Methylation of N-acetyl-5-HT to form melatonin (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-08)
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