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25(OH)D translocates from lysosomal lumen to cytosol
Stable Identifier
R-HSA-209766
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
,
lysosomal lumen
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Vitamin D (calciferol) metabolism (Homo sapiens)
25(OH)D translocates from lysosomal lumen to cytosol (Homo sapiens)
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Once out of the lysosome, 25-hydroxyvitamin D (calcidiol, 25(OH)D) translocates to the mitochondion where it is made available to the mitochondrial membrane-resident protein CYP27B1 for further hydroxylation. The mechanism of mitochondrial targeting is unknown but may involve some kind of intracellular vitamin D binding protein (IDBP). IDBPs are related to the hsc-70 family of heat shock proteins and may function to localise vitamin D metabolites to specific areas. No human IDBP has yet been characterised (Radons 2016).
Literature References
PubMed ID
Title
Journal
Year
26865365
The human HSP70 family of chaperones: where do we stand?
Radons, J
Cell Stress Chaperones
2016
Participants
Input
25(OH)D [lysosomal lumen]
Output
25(OH)D [cytosol]
Participates
as an event of
Vitamin D (calciferol) metabolism (Homo sapiens)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2008-05-28)
Created
Jassal, B (2008-01-07)
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