25(OH)D translocates from lysosomal lumen to cytosol

Stable Identifier
R-HSA-209766
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, lysosomal lumen
ReviewStatus
5/5
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25(OH)D translocates from lysosomal lumen to cytosol
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Once out of the lysosome, 25-hydroxyvitamin D (calcidiol, 25(OH)D) translocates to the mitochondion where it is made available to the mitochondrial membrane-resident protein CYP27B1 for further hydroxylation. The mechanism of mitochondrial targeting is unknown but may involve some kind of intracellular vitamin D binding protein (IDBP). IDBPs are related to the hsc-70 family of heat shock proteins and may function to localise vitamin D metabolites to specific areas. No human IDBP has yet been characterised (Radons 2016).
Literature References
PubMed ID Title Journal Year
26865365 The human HSP70 family of chaperones: where do we stand?

Radons, J

Cell Stress Chaperones 2016
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Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-07)
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