Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen

Stable Identifier
R-HSA-209760
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, lysosomal lumen
ReviewStatus
5/5
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Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen
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The internalized CUBN:GC:25(OH)D complex enters the lysosome where it can be acted upon the protease legumain (Halfon et al. 1998, Chen et al. 2000).
Literature References
PubMed ID Title Journal Year
9821970 Autocatalytic activation of human legumain at aspartic acid residues

Halfon, S, Patel, S, Vega, F, Zurawski, S, Zurawski, G

FEBS Lett 1998
11085925 Activation of human prolegumain by cleavage at a C-terminal asparagine residue

Chen, JM, Fortunato, M, Barrett, AJ

Biochem J 2000
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as an event of
Event Information
Go Biological Process
intracellular lipid transport (0032365)
Orthologous Events
Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Bos taurus)
Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Rattus norvegicus)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-01-07)
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