Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen

Stable Identifier
R-HSA-209760
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The internalized CUBN:GC:25(OH)D complex enters the lysosome where it can be acted upon the protease legumain (Halfon et al. 1998, Chen et al. 2000).

Literature References
PubMed ID Title Journal Year
11085925 Activation of human prolegumain by cleavage at a C-terminal asparagine residue

Chen, JM, Fortunato, M, Barrett, AJ

Biochem J 2000
9821970 Autocatalytic activation of human legumain at aspartic acid residues

Halfon, S, Patel, S, Vega, F, Zurawski, S, Zurawski, G

FEBS Lett 1998
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