Reactome | Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen

Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen

Stable Identifier

R-HSA-209760

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, lysosomal lumen

ReviewStatus

5/5

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Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen

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The internalized CUBN:GC:25(OH)D complex enters the lysosome where it can be acted upon the protease legumain (Halfon et al. 1998, Chen et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
9821970	Autocatalytic activation of human legumain at aspartic acid residues Zurawski, S, Halfon, S, Zurawski, G, Vega, F, Patel, S	FEBS Lett	1998
11085925	Activation of human prolegumain by cleavage at a C-terminal asparagine residue Barrett, AJ, Chen, JM, Fortunato, M	Biochem J	2000