Reactome | AGO2 [cytosol]

AGO2 [cytosol]

Stable Identifier

R-HSA-209723

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

EIF2C2, Argonaute-2

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Locations in the PathwayBrowser for interactor UniProt:Q02790 FKBP4

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External Reference Information

External Reference

UniProt:Q9UKV8 AGO2

Gene Names

AGO2, EIF2C2

Chain

chain:1-859

Reference Genes

BioGPS Gene:27161 AGO2

COSMIC (genes):AGO2 AGO2

CTD Gene:27161 AGO2

dbSNP Gene:27161 AGO2

ENSEMBL:ENSG00000123908 AGO2

ENSEMBL_homo_sapiens_GENE:ENSG00000123908.12 AGO2

HGNC:3263 AGO2

KEGG Gene (Homo sapiens):27161 AGO2

Monarch:27161 AGO2

NCBI Gene:27161 AGO2

OMIM:606229 AGO2

UCSC:Q9UKV8 AGO2

Reference Transcript

Other Identifiers

11754098_a_at

1561042_PM_at

1561042_at

17081706

17081708

213310_PM_at

213310_at

225569_PM_at

225569_at

225827_PM_at

225827_at

243304_PM_at

243304_at

27161

3156186

3156188

3156190

3156192

3156194

3156195

3156196

3156197

3156198

3156199

3156200

3156201

3156202

3156203

3156204

3156205

3156206

3156207

3156208

3156209

3156210

3156214

3156215

3156219

3156220

3156221

3156224

3156225

3156227

3156228

3156234

3156235

3156238

3156239

3156241

3156243

3156244

3156247

3156249

3156263

3156264

3156274

3156275

3156292

38505_at

48698_at

56226_at

58633_s_at

65694_at

8153201

82897_at

A_19_P00317929

A_23_P112159

A_33_P3651911

GE56259

GE87268

GO:0000340

GO:0000932

GO:0000993

GO:0001046

GO:0003676

GO:0003677

GO:0003723

GO:0003725

GO:0003727

GO:0003729

GO:0003743

GO:0003824

GO:0004518

GO:0004519

GO:0004521

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005845

GO:0006351

GO:0006355

GO:0006412

GO:0006413

GO:0006417

GO:0009791

GO:0010501

GO:0010586

GO:0010628

GO:0016020

GO:0016071

GO:0016442

GO:0016787

GO:0016891

GO:0022414

GO:0030422

GO:0030425

GO:0031047

GO:0031054

GO:0035194

GO:0035196

GO:0035197

GO:0035198

GO:0035278

GO:0035279

GO:0035925

GO:0036464

GO:0042985

GO:0043226

GO:0045182

GO:0045727

GO:0045766

GO:0045944

GO:0045947

GO:0046872

GO:0048856

GO:0048870

GO:0060213

GO:0061980

GO:0065003

GO:0070062

GO:0070551

GO:0070578

GO:0070922

GO:0090624

GO:0090625

GO:0098808

GO:0140098

GO:1900153

GO:1901135

GO:1901165

GO:1990904

HMNXSV003039023

HMNXSV003055196

Hs.146082.0.A1_3p_at

Hs.193053.0.A1_3p_at

Hs.193053.1.A1_3p_at

Hs.324504.1.A1_3p_at

Hs2.287797.8.S1_3p_at

ILMN_1695719

PH_hs_0026253

PH_hs_0040296

TC08001683.hg

TC08001684.hg

TC08002551.hg

p15964

p26467

Participates

as a component of

as an input of

AGO2 binds maternal endosiRNA (Homo sapiens)

as a member of

AGO1,2,3,4 [cytosol] (Homo sapiens)

Other forms of this molecule

AGO2 [nucleoplasm]

Inferred To

alg-1 [cytosol] (Caenorhabditis elegans)

AGO2 [cytosol] (Bos taurus)

AGO2 [cytosol] (Canis familiaris)

AGO2 [cytosol] (Gallus gallus)

AGO2 [cytosol] (Mus musculus)

AGO2 [cytosol] (Rattus norvegicus)

AGO2 [cytosol] (Sus scrofa)

AGO2 [cytosol] (Xenopus tropicalis)

AGO1 [cytosol] (Drosophila melanogaster)

ago1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001158095.1, NP_036286.2

OpenTargets

ENSG00000123908

HPA

ENSG00000123908-AGO2

GeneCards

Q9UKV8

Ensembl

ENST00000519980, ENSG00000123908, ENSP00000430176, ENST00000220592, ENSP00000220592

PRO

Q9UKV8

Pharos - Targets

Q9UKV8

Orphanet

24337

PDB

8D6J, 7D7U, 6NIT, 3QX9, 3LUC, 5T7B, 4F3T, 4OLA, 3QX8, 7C6B, 4Z4I, 6RA4, 5WEA, 4OLB, 5JS2, 4W5T, 5JS1, 4W5R, 6N4O, 6CBD, 4Z4G, 4Z4H, 3LUJ, 4W5O, 3LUH, 4Z4E, 3LUK, 4W5Q, 4Z4F, 3LUG, 4Z4D, 6MFN, 7KI3, 6MFR, 6MDZ, 3LUD, 8D71, 4W5N, 5KI6, 4Z4C

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NDV7 TNRC6A	2	TNRC6A [nucleoplasm] (R-HSA-5578976) TNRC6A [cytosol] (R-HSA-427769)	0.956	23
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.946	21
UniProt:Q15633 TARBP2	2	TARBP2 [cytosol] (R-HSA-203864) p-TARBP2 [cytosol] (R-HSA-9835348)	0.932	12
UniProt:Q9UPQ9 TNRC6B	1	TNRC6B [cytosol] (R-HSA-427777)	0.93	14
UniProt:Q9UPY3-1 DICER1			0.896	14
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.808	15
UniProt:Q9HCJ0 TNRC6C	1	TNRC6C [cytosol] (R-HSA-427776)	0.784	5
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.723	7
UniProt:Q9UGP4 LIMD1	1	LIMD1 [cytosol] (R-HSA-8932473)	0.694	11
UniProt:O15397 IPO8	2	IPO8 [cytosol] (R-HSA-5578740) IPO8 [nucleoplasm] (R-HSA-5578747)	0.688	4
UniProt:Q9UPQ9-2 TNRC6B			0.684	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.679	11
UniProt:Q9H9G7 AGO3	1	EIF2C3 [cytosol] (R-HSA-210615)	0.643	3
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.643	6
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.641	3
UniProt:Q9HA38 ZMAT3			0.602	5
UniProt:Q6IQ23 PKHA7			0.571	7
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.564	2
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.564	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.564	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P55265-5 ADAR			0.532	4
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.527	3
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.527	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	3
UniProt:Q13541 EIF4EBP1	2	EIF4EBP1 [cytosol] (R-HSA-72580) p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685)	0.524	2
UniProt:A7MCY6 TBKB1			0.499	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.499	3
UniProt:Q86UE4 LYRIC			0.499	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.499	2
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.499	2
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.499	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.499	3
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.499	4
UniProt:Q96C10 DHX58	1	DHX58 [cytosol] (R-HSA-913540)	0.499	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.483	2
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.483	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.462	2
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.462	2

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