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PLXND1 [plasma membrane]
Stable Identifier
R-HSA-209637
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Plexin-D1, PXD1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Other semaphorin interactions (Homo sapiens)
SEMA3E binds to PLXND1 (Homo sapiens)
PLXND1 [plasma membrane] (Homo sapiens)
SEMA3A:PLXND1 [plasma membrane] (Homo sapiens)
PLXND1 [plasma membrane] (Homo sapiens)
SEMA4A binds to PLXND1 (Homo sapiens)
PLXND1 [plasma membrane] (Homo sapiens)
SEMA4A:PLXND1 [plasma membrane] (Homo sapiens)
PLXND1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes (Homo sapiens)
PLXND1 [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RND2 GTPase cycle (Homo sapiens)
RND2 binds effectors (Homo sapiens)
RND2 effectors [cytosol] (Homo sapiens)
PLXND1 [plasma membrane] (Homo sapiens)
RND2:GTP:RND2 effectors [plasma membrane] (Homo sapiens)
RND2 effectors [cytosol] (Homo sapiens)
PLXND1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4D7 PLXND1
Gene Names
PLXND1, KIAA0620
Chain
signal peptide:1-46, chain:47-1925
Reference Genes
BioGPS Gene:23129 PLXND1
COSMIC (genes):PLXND1 PLXND1
CTD Gene:23129 PLXND1
dbSNP Gene:23129 PLXND1
ENSEMBL:ENSG00000004399 PLXND1
HGNC:9107 PLXND1
KEGG:hsa:23129 PLXND1
Monarch:23129 PLXND1
NCBI Gene:23129 PLXND1
OMIM:604282 PLXND1
UCSC:Q9Y4D7 PLXND1
Reference Transcript
RefSeq:NM_015103.2 PLXND1
Other Identifiers
11729203_a_at
11751084_s_at
16959007
212235_PM_at
212235_at
23129
2694818
2694819
2694820
2694821
2694822
2694823
2694824
2694825
2694826
2694827
2694828
2694829
2694830
2694831
2694832
2694833
2694834
2694835
2694836
2694837
2694838
2694839
2694840
2694841
2694842
2694843
2694844
2694845
2694846
2694848
2694849
2694851
2694852
2694853
2694856
2694859
2694860
2694861
2694862
2694863
2694864
2694865
2694866
2694868
2694869
2694870
2694871
2694872
2694873
2694874
2694879
2694880
2694882
2694883
2694886
2694887
2694888
2694890
2694891
2694892
2694893
2694894
2694898
2694903
2694904
2694905
2694906
2694907
2694908
2694909
2694910
2694911
2694912
2694913
2694914
38671_PM_at
38671_at
8090591
A_23_P80752
A_24_P376391
GE53337
GO:0001525
GO:0001569
GO:0001822
GO:0002116
GO:0003151
GO:0003279
GO:0005515
GO:0005886
GO:0007162
GO:0007416
GO:0008039
GO:0008360
GO:0016020
GO:0017154
GO:0019904
GO:0030027
GO:0030334
GO:0030424
GO:0031258
GO:0034330
GO:0035904
GO:0042995
GO:0043524
GO:0043542
GO:0044297
GO:0045765
GO:0048856
GO:0048870
GO:0050772
GO:0060089
GO:0060666
GO:0060976
GO:0071526
GO:0098978
HMNXSV003040134
Hs.301685.0.S1_3p_s_at
ILMN_1675222
PH_hs_0015557
TC03001772.hg
Participates
as a member of
RND2 effectors [cytosol] (Homo sapiens)
as an output of
PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes (Homo sapiens)
as a component of
SEMA3A:PLXND1 [plasma membrane] (Homo sapiens)
SEMA4A:PLXND1 [plasma membrane] (Homo sapiens)
as an input of
SEMA3E binds to PLXND1 (Homo sapiens)
SEMA4A binds to PLXND1 (Homo sapiens)
Inferred To
plxnd1 [plasma membrane]
(Danio rerio)
plxnd1 [plasma membrane]
(Xenopus tropicalis)
Plxnd1 [plasma membrane]
(Mus musculus)
Plxnd1 [plasma membrane]
(Rattus norvegicus)
PLXND1 [plasma membrane]
(Bos taurus)
PLXND1 [plasma membrane]
(Canis familiaris)
PLXND1 [plasma membrane]
(Gallus gallus)
PLXND1 [plasma membrane]
(Sus scrofa)
PlexA [plasma membrane]
(Drosophila melanogaster)
plx-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_055918.2
ENSEMBL
ENSP00000317128
,
ENST00000324093
OpenTargets
ENSG00000004399
HPA
ENSG00000004399-PLXND1
PRO
Q9Y4D7
Pharos - Targets
Q9Y4D7
GlyGen
Q9Y4D7
Orphanet
PLXND1
PDB
3H6N
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H3S1 SEMA4A
1
SEMA4A [plasma membrane]
(R-HSA-198232)
0.558
2
UniProt:O15041 SEMA3E
1
SEMA3E [extracellular region]
(R-HSA-198226)
0.558
2
UniProt:P09067 HXB5
0.556
3
UniProt:P70275
1
Sema3e [extracellular region]
(R-MMU-198226)
0.524
2
UniProt:P22736 NR4A1
2
p-S351-NR4A1 [nucleoplasm]
(R-HSA-199846)
NR4A1 [nucleoplasm]
(R-HSA-199831)
0.508
2
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