p75NTR:NgR complex interacts with the axonal inhibitor LINGO1

Stable Identifier
R-HSA-209573
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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p75NTR:NgR complex interacts with the axonal inhibitor LINGO1
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The NgR1:p75NTR complex also interacts with LINGO1, a nervous system-specific transmembrane protein. LINGO1 is a potent axonal inhibitor of oligodendrocyte differentiation and myelination, and is regulated by NGF and its receptor TRKA .

Literature References
PubMed ID Title Journal Year
14966521 LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Mi, S, Lee, X, Shao, Z, Thill, G, Ji, B, Relton, J, Levesque, M, Allaire, N, Perrin, S, Sands, B, Crowell, T, Cate, RL, McCoy, JM, Pepinsky, RB

Nat Neurosci 2004
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Orthologous Events
p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Canis familiaris)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-19)
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