Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex

Stable Identifier
R-HSA-209063
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 is ubiquitinated
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SCF (Beta-TrCP) ubiquitinates phosphorylated I kappa B alpha.

Literature References
PubMed ID Title Journal Year
10514433 Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

Hattori, K, Hatakeyama, S, Shirane, M, Matsumoto, M, Nakayama, K

J Biol Chem 1999
9990852 The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Winston, JT, Strack, P, Beer-Romero, P, Chu, CY, Elledge, SJ, Harper, JW

Genes Dev 1999
7628694 Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

Chen, Z, Hagler, J, Palombella, VJ, Melandri, F, Scherer, D, Ballard, D, Maniatis, T

Genes Dev 1995
9990853 Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

Spencer, E, Jiang, J, Chen, ZJ

Genes Dev 1999
9859996 Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Yaron, A, Hatzubai, A, Davis, M, Lavon, I, Amit, S, Manning, AM, Andersen, JS, Mann, M, Mercurio, F, Ben-Neriah, Y

Nature 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created