Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex

Stable Identifier
R-HSA-209063
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 is ubiquitinated
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SCF (Beta-TrCP) ubiquitinates phosphorylated I kappa B alpha.

Literature References
PubMed ID Title Journal Year
9990852 The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Strack, P, Elledge, SJ, Beer-Romero, P, Chu, CY, Winston, JT, Harper, JW

Genes Dev 1999
10514433 Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

Matsumoto, M, Hatakeyama, S, Shirane, M, Hattori, K, Nakayama, K

J Biol Chem 1999
7628694 Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

Scherer, D, Chen, Z, Hagler, J, Palombella, VJ, Ballard, D, Maniatis, T, Melandri, F

Genes Dev 1995
9990853 Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

Jiang, J, Spencer, E, Chen, ZJ

Genes Dev 1999
9859996 Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Andersen, JS, Mann, M, Lavon, I, Manning, AM, Hatzubai, A, Amit, S, Mercurio, F, Yaron, A, Davis, M, Ben-Neriah, Y

Nature 1998
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
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