Reactome | Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex

Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex

Stable Identifier

R-HSA-209063

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 is ubiquitinated

ReviewStatus

5/5

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Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex

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SCF (Beta-TrCP) ubiquitinates phosphorylated I kappa B alpha.

Literature References

PubMed ID	Title	Journal	Year
9990852	The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro Strack, P, Elledge, SJ, Beer-Romero, P, Chu, CY, Winston, JT, Harper, JW	Genes Dev	1999
10514433	Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha Matsumoto, M, Hatakeyama, S, Shirane, M, Hattori, K, Nakayama, K	J Biol Chem	1999
7628694	Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway Scherer, D, Chen, Z, Hagler, J, Palombella, VJ, Ballard, D, Maniatis, T, Melandri, F	Genes Dev	1995
9990853	Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP Jiang, J, Spencer, E, Chen, ZJ	Genes Dev	1999
9859996	Identification of the receptor component of the IkappaBalpha-ubiquitin ligase Andersen, JS, Mann, M, Lavon, I, Manning, AM, Hatzubai, A, Amit, S, Mercurio, F, Yaron, A, Davis, M, Ben-Neriah, Y	Nature	1998