STIM1 binds TRPC1 forming STIM1:TRPC1 complex

Stable Identifier
Reaction [binding]
Homo sapiens
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The polybasic region of STIM1 interacts with 2 aspartate residues in the C-terminal region of TRPC1 (Zeng et al. 2008, Huang et al. 2006). The STIM1:TRPC1 complex can form a tenary complex with ORAI1 (Ong et al. 2007, Jardin et al. 2008) and ORAI participates in function of STIM1:TRPC1 channels (Cheng et al. 2008, Cheng et al. 2011). As inferred from chicken DT40 cells, TRPC1 (and possibly other TRP channels) participates in store-operated calcium influx during signaling by the B cell receptor (Mori et al. 2002).

Literature References
PubMed ID Title Journal Year
18420269 STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts

Alfonso, S, Angélica, Z, Vaca, L, Alicia, S, Carlos, S

Cell Calcium 2008
18995841 STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction

Yuan, JP, Muallem, S, Kim, MS, Huang, GN, Choi, YJ, Zeng, W, Worley, PF

Mol Cell 2008
17486119 STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels

Yuan, JP, Muallem, S, Huang, GN, Zeng, W, Worley, PF

Nat Cell Biol 2007
16906149 STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels

Yuan, JP, Muallem, S, Huang, GN, Zeng, W, Han, L, Kim, JY, Worley, PF

Nat Cell Biol 2006
18326500 Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels

Ong, HL, Ambudkar, IS, Liu, X, Cheng, KT

J Biol Chem 2008
11901194 Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes

Iino, M, Kurosaki, M, Gotoh, K, Hara, Y, Okada, T, Kurosaki, T, Miyakawa, T, Hirose, K, Mizushima, A, Nishida, M, Penner, R, Wakamori, M, Fleig, A, Mori, Y, Hermosura, M, Mori, E

J Exp Med 2002
22210847 The Ca2+ Sensor STIM1 is Necessary and Sufficient for the Store-Operated Ca2+ Entry Function of TRPCs in Endothelial Cells

Freichel, M, Tiruppathi, C, Yuan, JP, Malik, AB, Vogel, SM, Sundivakkam, PC, Flockerzi, V, Singh, V

Mol Pharmacol 2011
18843204 Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1

Jardin, I, Rosado, JA, Salido, GM

Channels (Austin) 2008
17224452 Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components

Gwack, Y, Ong, HL, Bandyopadhyay, BC, Ambudkar, IS, Srikanth, S, Liu, X, Singh, BB, Pani, B, Paria, BC, Gill, DL, Soboloff, J, Cheng, KT

J Biol Chem 2007
21408196 Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions

Swaim, W, Ong, HL, Ambudkar, IS, Liu, X, Cheng, KT

PLoS Biol 2011
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