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HS(5)-GPC2 [plasma membrane]
Stable Identifier
R-HSA-2076624
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GPC2, Glypican-2 component recommendedName: Secreted glypican-2 /component, GPC2_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
sG binds to HSPGs (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
HSPGs:sG [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
Respiratory syncytial virus (RSV) attachment and entry (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(5)-PGs [plasma membrane] (Homo sapiens)
HS(5)-GPC2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N158 GPC2
Gene Names
GPC2
Chain
signal peptide:1-23, chain:24-554, chain:24-, propeptide:555-579
Reference Genes
BioGPS Gene:221914 GPC2
COSMIC (genes):GPC2 GPC2
CTD Gene:221914 GPC2
dbSNP Gene:221914 GPC2
ENSEMBL:ENSG00000213420 GPC2
HGNC:4450 GPC2
KEGG:hsa:221914 GPC2
Monarch:221914 GPC2
NCBI Gene:221914 GPC2
OMIM:618446 GPC2
UCSC:Q8N158 GPC2
Reference Transcript
RefSeq:NM_152742.2 GPC2
Other Identifiers
11731828_at
11731829_x_at
17060515
221914
239422_3p_at
239422_PM_at
239422_at
3063808
3063809
3063810
3063811
3063812
3063813
3063814
3063815
3063816
3063817
3063819
3063820
3063821
3063822
3063823
3063824
3063825
3063826
3063827
3063829
3063830
8141463
8141466
GE480275
GO:0005515
GO:0005576
GO:0005783
GO:0005794
GO:0005796
GO:0005886
GO:0007224
GO:0009966
GO:0009986
GO:0010976
GO:0016477
GO:0030154
GO:0030182
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0045202
GO:0048870
GO:0062023
GO:0098552
GO:1905475
HMNXSV003033372
Hs.211701.0.A1_3p_at
Hs.211701.0.A1_3p_x_at
ILMN_1651642
PH_hs_0012283
TC07001662.hg
Participates
as a member of
HS(5)-PGs [plasma membrane] (Homo sapiens)
Other forms of this molecule
HS(4)-GPC2 [plasma membrane]
HS(6)-GPC2 [plasma membrane]
HS(2)-GPC2 [plasma membrane]
HS(1)-GPC2 [plasma membrane]
HS(3)-GPC2 [plasma membrane]
XylS-GPC2 [Golgi lumen]
Gal-Xyl-GPC2 [Golgi lumen]
GPC2 [Golgi lumen]
Gal-Gal-Xyl-GPC2 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC2 [Golgi lumen]
HS(3)-GPC2 [Golgi lumen]
HS(4)-GPC2 [Golgi lumen]
HS(2)-GPC2 [Golgi lumen]
HS(1)-GPC2 [Golgi lumen]
Heparan(4)-GPC2 [Golgi lumen]
Heparan(3)-GPC2 [Golgi lumen]
Heparan(2)-GPC2 [Golgi lumen]
Heparan(1)-GPC2 [Golgi lumen]
Heparan-GPC2 [Golgi lumen]
HS(5)-GPC2 [Golgi lumen]
HS(6)-GPC2 [Golgi lumen]
HS(6)-GPC2 [lysosomal lumen]
GPC2 [lysosomal lumen]
Inferred To
Gpc2 [plasma membrane]
(Mus musculus)
Gpc2 [plasma membrane]
(Rattus norvegicus)
HS(5)-GPC2 [plasma membrane]
(Caenorhabditis elegans)
gpc2 [plasma membrane]
(Danio rerio)
gpc2 [plasma membrane]
(Xenopus tropicalis)
GPC2 [plasma membrane]
(Bos taurus)
GPC2 [plasma membrane]
(Canis familiaris)
GPC2 [plasma membrane]
(Sus scrofa)
Homologues of HS(5)-GPC2 [plasma membrane]
(Caenorhabditis elegans)
lon-2 [plasma membrane]
(Caenorhabditis elegans)
gpn-1 [plasma membrane]
(Caenorhabditis elegans)
dlp [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63661) at unknown position
Modification
beta-D-IdoA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_689955.1
ENSEMBL
ENST00000292377
,
ENSP00000292377
OpenTargets
ENSG00000213420
HPA
ENSG00000213420-GPC2
PRO
Q8N158
Pharos - Targets
Q8N158
GlyGen
Q8N158
PDB
6WJL
,
7T62
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