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Heparan(1)-GPC2 [Golgi lumen]
Stable Identifier
R-HSA-2076600
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GPC2, Glypican-2 component recommendedName: Secreted glypican-2 /component, GPC2_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)
Heparan(1)-PGs [Golgi lumen] (Homo sapiens)
Heparan(1)-GPC2 [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)
Heparan(1)-PGs [Golgi lumen] (Homo sapiens)
Heparan(1)-GPC2 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)
Heparan(1)-PGs [Golgi lumen] (Homo sapiens)
Heparan(1)-GPC2 [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)
Heparan(1)-PGs [Golgi lumen] (Homo sapiens)
Heparan(1)-GPC2 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N158 GPC2
Gene Names
GPC2
Chain
signal peptide:1-23, chain:24-554, chain:24-, propeptide:555-579
Reference Genes
BioGPS Gene:221914 GPC2
COSMIC (genes):GPC2 GPC2
CTD Gene:221914 GPC2
dbSNP Gene:221914 GPC2
ENSEMBL:ENSG00000213420 GPC2
ENSEMBL_homo_sapiens_GENE:ENSG00000213420.8 GPC2
HGNC:4450 GPC2
KEGG Gene (Homo sapiens):221914 GPC2
Monarch:221914 GPC2
NCBI Gene:221914 GPC2
OMIM:618446 GPC2
UCSC:Q8N158 GPC2
Reference Transcript
RefSeq:NM_152742.2 GPC2
Other Identifiers
11731828_at
11731829_x_at
17060515
221914
239422_3p_at
239422_PM_at
239422_at
3063808
3063809
3063810
3063811
3063812
3063813
3063815
3063816
3063817
3063819
3063823
3063825
3063826
3063827
3063829
3063830
8141463
8141466
GE480275
GO:0005515
GO:0005576
GO:0005764
GO:0005773
GO:0005783
GO:0005794
GO:0005796
GO:0005886
GO:0007224
GO:0009966
GO:0009986
GO:0010976
GO:0016020
GO:0016477
GO:0023052
GO:0030154
GO:0030182
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0045202
GO:0048856
GO:0048870
GO:0062023
GO:0098552
GO:1905475
HMNXSV003033372
Hs.211701.0.A1_3p_at
Hs.211701.0.A1_3p_x_at
ILMN_1651642
PH_hs_0012283
TC07001662.hg
Participates
as a member of
Heparan(1)-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
GPC2 [lysosomal lumen]
HS(6)-GPC2 [lysosomal lumen]
HS(1)-GPC2 [Golgi lumen]
HS(2)-GPC2 [Golgi lumen]
HS(3)-GPC2 [Golgi lumen]
HS(4)-GPC2 [Golgi lumen]
HS(6)-GPC2 [Golgi lumen]
HS(5)-GPC2 [Golgi lumen]
Heparan-GPC2 [Golgi lumen]
Heparan(2)-GPC2 [Golgi lumen]
Heparan(4)-GPC2 [Golgi lumen]
Heparan(3)-GPC2 [Golgi lumen]
HS(4)-GPC2 [plasma membrane]
HS(6)-GPC2 [plasma membrane]
HS(2)-GPC2 [plasma membrane]
HS(1)-GPC2 [plasma membrane]
HS(3)-GPC2 [plasma membrane]
HS(5)-GPC2 [plasma membrane]
Gal-Gal-Xyl-GPC2 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC2 [Golgi lumen]
Gal-Xyl-GPC2 [Golgi lumen]
XylS-GPC2 [Golgi lumen]
GPC2 [Golgi lumen]
Inferred To
Heparan(1)-GPC2 [Golgi lumen]
(Caenorhabditis elegans)
Gpc2 [Golgi lumen]
(Mus musculus)
Gpc2 [Golgi lumen]
(Rattus norvegicus)
GPC2 [Golgi lumen]
(Bos taurus)
GPC2 [Golgi lumen]
(Canis familiaris)
GPC2 [Golgi lumen]
(Sus scrofa)
dlp [Golgi lumen]
(Drosophila melanogaster)
gpc2 [Golgi lumen]
(Danio rerio)
gpc2 [Golgi lumen]
(Xenopus tropicalis)
lon-2 [Golgi lumen]
(Caenorhabditis elegans)
gpn-1 [Golgi lumen]
(Caenorhabditis elegans)
Homologues of Heparan(1)-GPC2 [Golgi lumen]
(Caenorhabditis elegans)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63646) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_689955.1
OpenTargets
ENSG00000213420
HPA
ENSG00000213420-GPC2
GeneCards
Q8N158
Ensembl
ENST00000292377
,
ENSP00000292377
,
ENSG00000213420
PRO
Q8N158
Pharos - Targets
Q8N158
PDB
7T62
,
6WJL
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