CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992). Experiments in mice indicate that PI3K associated with CD19 is partly responsible for the activity (Buhl et al. 1997, Otero et al. 2001, Aiba et al. 2008). (PI3K associated with BCAP is also partly responsible (Aiba et al. 2008).)

Literature References
PubMed ID Title Journal Year
9235916 p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

Chantry, D, Vojtek, A, Kashishian, A, Holtzman, DA, Wood, C, Gray, PW, Cooper, JA, Hoekstra, MF

J Biol Chem 1997
18025150 Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase

Aiba, Y, Kameyama, M, Yamazaki, T, Tedder, TF, Kurosaki, T

Blood 2008
9382888 Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization

Buhl, AM, Pleiman, CM, Rickert, RC, Cambier, JC

J Exp Med 1997
1372019 Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes

Gold, MR, Chan, VW, Turck, CW, DeFranco, AL

J Immunol 1992
11042164 Cd19-dependent activation of Akt kinase in B-lymphocytes

Otero, DC, Omori, SA, Rickert, RC

J Biol Chem 2001
Participant Of
Catalyst Activity
Catalyst Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of CD19 Signalosome [plasma membrane]
Physical Entity
Orthologous Events
Cite Us!