CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

Stable Identifier
Reaction [transition]
Homo sapiens
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PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992). Experiments in mice indicate that PI3K associated with CD19 is partly responsible for the activity (Buhl et al. 1997, Otero et al. 2001, Aiba et al. 2008). (PI3K associated with BCAP is also partly responsible (Aiba et al. 2008).)
Literature References
PubMed ID Title Journal Year
18025150 Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase

Aiba, Y, Tedder, TF, Yamazaki, T, Kurosaki, T, Kameyama, M

Blood 2008
9235916 p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

Gray, PW, Hoekstra, MF, Holtzman, DA, Kashishian, A, Wood, C, Vojtek, A, Chantry, D, Cooper, JA

J Biol Chem 1997
9382888 Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization

Rickert, RC, Pleiman, CM, Buhl, AM, Cambier, JC

J Exp Med 1997
1372019 Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes

Turck, CW, Gold, MR, Chan, VW, DeFranco, AL

J Immunol 1992
11042164 Cd19-dependent activation of Akt kinase in B-lymphocytes

Rickert, RC, Otero, DC, Omori, SA

J Biol Chem 2001
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of CD19 Signalosome [plasma membrane]

Orthologous Events
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