PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992). Experiments in mice indicate that PI3K associated with CD19 is partly responsible for the activity (Buhl et al. 1997, Otero et al. 2001, Aiba et al. 2008). (PI3K associated with BCAP is also partly responsible (Aiba et al. 2008).)
Aiba, Y, Tedder, TF, Yamazaki, T, Kurosaki, T, Kameyama, M
Gray, PW, Hoekstra, MF, Holtzman, DA, Kashishian, A, Wood, C, Vojtek, A, Chantry, D, Cooper, JA
Rickert, RC, Pleiman, CM, Buhl, AM, Cambier, JC
Turck, CW, Gold, MR, Chan, VW, DeFranco, AL
Rickert, RC, Otero, DC, Omori, SA
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of CD19 Signalosome [plasma membrane]
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