Reactome | CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

Stable Identifier

R-HSA-2076220

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

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PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992). Experiments in mice indicate that PI3K associated with CD19 is partly responsible for the activity (Buhl et al. 1997, Otero et al. 2001, Aiba et al. 2008). (PI3K associated with BCAP is also partly responsible (Aiba et al. 2008).)

Literature References

PubMed ID	Title	Journal	Year
18025150	Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase Aiba, Y, Kameyama, M, Yamazaki, T, Tedder, TF, Kurosaki, T	Blood	2008
9235916	p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes Chantry, D, Vojtek, A, Kashishian, A, Holtzman, DA, Wood, C, Gray, PW, Cooper, JA, Hoekstra, MF	J Biol Chem	1997
9382888	Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization Buhl, AM, Pleiman, CM, Rickert, RC, Cambier, JC	J Exp Med	1997
1372019	Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes Gold, MR, Chan, VW, Turck, CW, DeFranco, AL	J Immunol	1992
11042164	Cd19-dependent activation of Akt kinase in B-lymphocytes Otero, DC, Omori, SA, Rickert, RC	J Biol Chem	2001