GP369 inhibits activation of amplified FGFR2 signaling

Stable Identifier
R-HSA-2067713
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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GP369 inhibits activation of amplified FGFR2 signaling
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Treatment of FGFR2-amplified gastric and breast cancer cell lines with the antibody GP369 inhibits FGFR2 phosphorylation and downstream signaling and suppresses cell proliferation. Treatment of mice with GP369 inhibits the growth of human cancer xenografts carrying activating FGFR2 mutations. The GP369-binding epitope is contained in the ligand-binding region of the receptor, suggesting that the antibody works by disrupting the ligand-dependent activation of amplified FGFR2 (Bai, 2010).
Literature References
PubMed ID Title Journal Year
20709759 GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling

Poling, LL, Bai, A, Chen, T, Vo, NY, Gyuris, J, Ismail, NS, Jiang, J, Weiler, S, Weng, Z, Winston, WM, Kollipara, S, Lerner, L, Mazsa, EK, Meetze, K

Cancer Res 2010
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Input
Output
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as an event of
Functional status

Gain of function of Overexpressed FGFR2 homodimers [plasma membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2012-02-10)
Reviewed
Ezzat, S  (2012-05-15)
Created
Rothfels, K  (2012-01-26)
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