Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase

Stable Identifier
R-HSA-2066788
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The final step in the beta-oxidation process is the thiolytic cleavage of 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA to form docosahexaenoyl-CoA (DHA-CoA). This step is catalysed by both sterol carrier protein X (SCPx) and the classic 3-ketoacyl-CoA thiolase (this reaction) (Ferdinandusse et al. 2001).

Literature References
PubMed ID Title Journal Year
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Hurt, E, Sprecher, H, Yoder, E, Moore, SA, Spector, AA

J Lipid Res 1995
11734571 Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Denis, S, Mooijer, PA, Wanders, RJA, Zhang, Z, Reddy, JK, Spector, AA, Ferdinandusse, S

J Lipid Res 2001
Participants
Participates
Catalyst Activity

acetate CoA-transferase activity of ACAA1 [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
Authored
Created
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