Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase

Stable Identifier
R-HSA-2066788
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase
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The final step in the beta-oxidation process is the thiolytic cleavage of 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA to form docosahexaenoyl-CoA (DHA-CoA). This step is catalysed by both sterol carrier protein X (SCPx) and the classic 3-ketoacyl-CoA thiolase (this reaction) (Ferdinandusse et al. 2001).
Literature References
PubMed ID Title Journal Year
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Hurt, E, Sprecher, H, Yoder, E, Moore, SA, Spector, AA

J Lipid Res 1995
11734571 Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Denis, S, Mooijer, PA, Wanders, RJA, Zhang, Z, Reddy, JK, Spector, AA, Ferdinandusse, S

J Lipid Res 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

acetate CoA-transferase activity of ACAA1 [peroxisomal matrix]

Physical Entity
ACAA1 [peroxisomal matrix] (Homo sapiens)
Activity
acetate CoA-transferase activity (GO:0008775)
Orthologous Events
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Bos taurus)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Canis familiaris)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Danio rerio)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Dictyostelium discoideum)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Gallus gallus)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Mus musculus)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Rattus norvegicus)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Saccharomyces cerevisiae)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Sus scrofa)
Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Xenopus tropicalis)
Cross References
Rhea
Authored
Garapati, P V  (2012-01-11)
Created
Garapati, P V  (2012-01-25)
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