Reactome | Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase

Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase

Stable Identifier

R-HSA-2066788

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

ReviewStatus

5/5

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Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase

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The final step in the beta-oxidation process is the thiolytic cleavage of 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA to form docosahexaenoyl-CoA (DHA-CoA). This step is catalysed by both sterol carrier protein X (SCPx) and the classic 3-ketoacyl-CoA thiolase (this reaction) (Ferdinandusse et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
8656081	Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid Hurt, E, Sprecher, H, Yoder, E, Moore, SA, Spector, AA	J Lipid Res	1995
11734571	Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid Denis, S, Mooijer, PA, Wanders, RJA, Zhang, Z, Reddy, JK, Spector, AA, Ferdinandusse, S	J Lipid Res	2001