Reactome | Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA

Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA

Stable Identifier

R-HSA-2066787

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

ReviewStatus

5/5

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Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA

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Retroconversion of C24:6(n-3) to docosahexaenoic acid (22:6(n-3) involves the initial oxidation of tetracosahexaenoyl-CoA to an intermediate 1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA (delta2-THA-CoA). This step is catalysed by the peroxisomal enzyme Straight-chain acyl-CoA oxidase (SCOX) (Ferdinandusse et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11500517	Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis Moser, AB, Watkins, PA, Su, HM, Moser, HW	J Biol Chem	2001
8656081	Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid Hurt, E, Sprecher, H, Yoder, E, Moore, SA, Spector, AA	J Lipid Res	1995
11734571	Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid Denis, S, Mooijer, PA, Wanders, RJA, Zhang, Z, Reddy, JK, Spector, AA, Ferdinandusse, S	J Lipid Res	2001