Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA

Stable Identifier
Reaction [transition]
Homo sapiens
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Retroconversion of C24:6(n-3) to docosahexaenoic acid (22:6(n-3) involves the initial oxidation of tetracosahexaenoyl-CoA to an intermediate 1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA (delta2-THA-CoA). This step is catalysed by the peroxisomal enzyme Straight-chain acyl-CoA oxidase (SCOX) (Ferdinandusse et al. 2001).

Literature References
PubMed ID Title Journal Year
11500517 Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis

Moser, AB, Watkins, PA, Su, HM, Moser, HW

J Biol Chem 2001
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Hurt, E, Sprecher, H, Yoder, E, Moore, SA, Spector, AA

J Lipid Res 1995
11734571 Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Denis, S, Mooijer, PA, Wanders, RJ, Zhang, Z, Reddy, JK, Spector, AA, Ferdinandusse, S

J Lipid Res 2001
Catalyst Activity

acyl-CoA oxidase activity of ACOX1 dimer [peroxisomal matrix]

Orthologous Events
Cross References
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