Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)

Stable Identifier
R-HSA-2066781
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The final step in the beta-oxidation process is the thiolytic cleavage of 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA to form docosahexaenoyl-CoA (DHA-CoA). This step is catalysed by both sterol carrier protein X (SCPx) (this reaction) and the classic 3-ketoacyl-CoA thiolase (Ferdinandusse et al. 2001).

Literature References
PubMed ID Title Journal Year
11734571 Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Ferdinandusse, S, Denis, S, Mooijer, PA, Zhang, Z, Reddy, JK, Spector, AA, Wanders, RJ

J Lipid Res 2001
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA

J Lipid Res 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

propionyl-CoA C2-trimethyltridecanoyltransferase activity of SCP2 [peroxisomal matrix]

Physical Entity
SCP2 [peroxisomal matrix] (Homo sapiens)
Activity
propionyl-CoA C2-trimethyltridecanoyltransferase activity (GO:0050632)
Authored
Garapati, P V  (2012-01-11)
Created
Garapati, P V  (2012-01-25)
Cite Us!