Reactome | Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)

Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)

Stable Identifier

R-HSA-2066781

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

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Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)

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The final step in the beta-oxidation process is the thiolytic cleavage of 1-(3-oxo-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA to form docosahexaenoyl-CoA (DHA-CoA). This step is catalysed by both sterol carrier protein X (SCPx) (this reaction) and the classic 3-ketoacyl-CoA thiolase (Ferdinandusse et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11734571	Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid Ferdinandusse, S, Denis, S, Mooijer, PA, Zhang, Z, Reddy, JK, Spector, AA, Wanders, RJ	J Lipid Res	2001
8656081	Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA	J Lipid Res	1995