Conversion of DHA-CoA to docosahexaenoic acid (DHA)

Stable Identifier
R-HSA-2066779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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Conversion of DHA-CoA to docosahexaenoic acid (DHA)
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DHA-CoA preferentially moves back to the ER, perhaps as a free fatty acid. This conversion is usually catalysed by acyl-CoA thioesterases (ACOTs). No specific acyl-CoA thioesterase enzyme has been identified for the peroxisomal metabolism of DHA-CoA, but the peroxisomal ACOT8 has a wide substrate specificity and is likely to be responsible (Ferdinandusse et al. 2003, Hunt & Alexson. 2008).
Literature References
PubMed ID Title Journal Year
18538142 Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism

Alexson, SE, Hunt, MC

Prog Lipid Res 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

acetyl-CoA hydrolase activity of ACOT8 [peroxisomal matrix]

Physical Entity
ACOT8 [peroxisomal matrix] (Homo sapiens)
Activity
acetyl-CoA hydrolase activity (GO:0003986)
Orthologous Events
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Bos taurus)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Caenorhabditis elegans)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Canis familiaris)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Danio rerio)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Gallus gallus)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Mus musculus)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Rattus norvegicus)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Saccharomyces cerevisiae)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Sus scrofa)
Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Xenopus tropicalis)
Cross References
Rhea
Authored
Garapati, P V  (2012-01-11)
Created
Garapati, P V  (2012-01-25)
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