Conversion of DHA-CoA to docosahexaenoic acid (DHA)

Stable Identifier
R-HSA-2066779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DHA-CoA preferentially moves back to the ER, perhaps as a free fatty acid. This conversion is usually catalysed by acyl-CoA thioesterases (ACOTs). No specific acyl-CoA thioesterase enzyme has been identified for the peroxisomal metabolism of DHA-CoA, but the peroxisomal ACOT8 has a wide substrate specificity and is likely to be responsible (Ferdinandusse et al. 2003, Hunt & Alexson. 2008).

Literature References
PubMed ID Title Journal Year
18538142 Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism

Hunt, MC, Alexson, SE

Prog Lipid Res 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetyl-CoA hydrolase activity of ACOT8 [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Authored
Created