Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA

Stable Identifier
R-HSA-2066778
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Delta2-THA-CoA is hydrated to 3-hydroxyacyl-CoA intermediate 1-(3-hydroxy-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA by HSD17B4/DBP (d-bifunctional protein) dimer.

Literature References
PubMed ID Title Journal Year
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA

J Lipid Res 1995
11500517 Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis

Su, HM, Moser, AB, Moser, HW, Watkins, PA

J Biol Chem 2001
11734571 Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid

Ferdinandusse, S, Denis, S, Mooijer, PA, Zhang, Z, Reddy, JK, Spector, AA, Wanders, RJ

J Lipid Res 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
long-chain-enoyl-CoA hydratase activity of HSD17B4 dimer [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Authored
Created