Reactome | Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA

Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA

Stable Identifier

R-HSA-2066778

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Delta2-THA-CoA is hydrated to 3-hydroxyacyl-CoA intermediate 1-(3-hydroxy-6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl)-CoA by HSD17B4/DBP (d-bifunctional protein) dimer.

Literature References

PubMed ID	Title	Journal	Year
8656081	Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA	J Lipid Res	1995
11500517	Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis Su, HM, Moser, AB, Moser, HW, Watkins, PA	J Biol Chem	2001
11734571	Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid Ferdinandusse, S, Denis, S, Mooijer, PA, Zhang, Z, Reddy, JK, Spector, AA, Wanders, RJ	J Lipid Res	2001