DVL2 binds phosphorylated WWTR1 (TAZ)

Stable Identifier
R-HSA-2066299
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated WWTR1 (TAZ) and DVL interact to form a complex in the cytosol. Thus sequestered, DVL2 is unable to undergo phosphorylation by casein kinase, inhibiting its role in WNT signaling. WWTR1 - DLV interaction thus appears to link the Hippo and WNT signaling processes (Varelas et al. 2010). The stoichiometry of the WWTR1:DVL complex is unknown.

Literature References
PubMed ID Title Journal Year
20412773 The Hippo pathway regulates Wnt/beta-catenin signaling

Varelas, X, Miller, BW, Sopko, R, Song, S, Gregorieff, A, Fellouse, FA, Sakuma, R, Pawson, T, Hunziker, W, McNeill, H, Wrana, JL, Attisano, L

Dev Cell 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created