DVL2 binds phosphorylated WWTR1 (TAZ)

Stable Identifier
R-HSA-2066299
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DVL2 binds phosphorylated WWTR1 (TAZ)
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Phosphorylated WWTR1 (TAZ) and DVL interact to form a complex in the cytosol. Thus sequestered, DVL2 is unable to undergo phosphorylation by casein kinase, inhibiting its role in WNT signaling. WWTR1 - DLV interaction thus appears to link the Hippo and WNT signaling processes (Varelas et al. 2010). The stoichiometry of the WWTR1:DVL complex is unknown.

Literature References
PubMed ID Title Journal Year
20412773 The Hippo pathway regulates Wnt/beta-catenin signaling

Pawson, T, Wrana, JL, Gregorieff, A, Sakuma, R, Fellouse, FA, Attisano, L, Varelas, X, Song, S, McNeill, H, Hunziker, W, Miller, BW, Sopko, R

Dev Cell 2010
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Orthologous Events
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Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-25)
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