Reactome | DVL2 binds phosphorylated WWTR1 (TAZ)

DVL2 binds phosphorylated WWTR1 (TAZ)

Stable Identifier

R-HSA-2066299

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylated WWTR1 (TAZ) and DVL interact to form a complex in the cytosol. Thus sequestered, DVL2 is unable to undergo phosphorylation by casein kinase, inhibiting its role in WNT signaling. WWTR1 - DLV interaction thus appears to link the Hippo and WNT signaling processes (Varelas et al. 2010). The stoichiometry of the WWTR1:DVL complex is unknown.

Literature References

PubMed ID	Title	Journal	Year
20412773	The Hippo pathway regulates Wnt/beta-catenin signaling Pawson, T, Wrana, JL, Gregorieff, A, Sakuma, R, Fellouse, FA, Attisano, L, Varelas, X, Song, S, McNeill, H, Hunziker, W, Miller, BW, Sopko, R	Dev Cell	2010