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REN(24-406) [plasma membrane]
Stable Identifier
R-HSA-2065391
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Prorenin, REN, RENI_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)
Prorenin-Prorenin Receptor [plasma membrane] (Homo sapiens)
REN(24-406) [plasma membrane] (Homo sapiens)
REN(24-406) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00797 REN
Gene Names
REN
Chain
signal peptide:1-23, propeptide:24-66, chain:67-406
Reference Genes
BioGPS Gene:5972 REN
COSMIC (genes):REN REN
CTD Gene:5972 REN
dbSNP Gene:5972 REN
ENSEMBL:ENSG00000143839 REN
HGNC:9958 REN
KEGG:hsa:5972 REN
Monarch:5972 REN
NCBI Gene:5972 REN
OMIM:179820 REN
UCSC:P00797 REN
Reference Transcript
RefSeq:NM_000537.3 REN
Other Identifiers
11722955_at
16698286
205563_at
206367_PM_at
206367_at
2451901
2451902
2451903
2451904
2451905
2451906
2451907
2451909
2451910
2451911
2451912
2451915
2451916
2451917
2451919
2451920
2451921
39655_at
5972
7923608
A_23_P34637
A_24_P919974
GE60508
GO:0001822
GO:0001823
GO:0002003
GO:0002016
GO:0002018
GO:0003014
GO:0003824
GO:0004175
GO:0004190
GO:0005102
GO:0005159
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006508
GO:0008217
GO:0008233
GO:0008584
GO:0009410
GO:0009755
GO:0016020
GO:0016787
GO:0022414
GO:0032496
GO:0035902
GO:0042756
GO:0043408
GO:0045177
GO:0048469
GO:0048856
GO:0050435
GO:0050886
GO:0051591
GO:0051604
GO:0070305
GO:0071466
GO:0072051
GO:0140096
HMNXSV003016678
ILMN_1669404
ILMN_1742272
M26901_s_at
PH_hs_0000397
PH_hs_0005191
TC01003726.hg
TC01006051.hg
g11125774_3p_at
g4504872_3p_at
Participates
as a component of
Prorenin-Prorenin Receptor [plasma membrane] (Homo sapiens)
Other forms of this molecule
REN [extracellular region]
REN [plasma membrane]
Inferred To
cathD [plasma membrane]
(Drosophila melanogaster)
CG10872 [plasma membrane]
(Drosophila melanogaster)
Bace [plasma membrane]
(Drosophila melanogaster)
asp-12 [plasma membrane]
(Caenorhabditis elegans)
asp-15 [plasma membrane]
(Caenorhabditis elegans)
asp-7 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG31928 [plasma membrane]
(Drosophila melanogaster)
asp-4 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG6508 [plasma membrane]
(Drosophila melanogaster)
asp-9 [plasma membrane]
(Caenorhabditis elegans)
asp-1 [plasma membrane]
(Caenorhabditis elegans)
asp-18 [plasma membrane]
(Caenorhabditis elegans)
REN [plasma membrane]
(Bos taurus)
REN [plasma membrane]
(Canis familiaris)
REN [plasma membrane]
(Sus scrofa)
hrg-7 [plasma membrane]
(Caenorhabditis elegans)
asp-6 [plasma membrane]
(Caenorhabditis elegans)
REN(24-406) [plasma membrane]
(Gallus gallus)
asp-3 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG10104 [plasma membrane]
(Drosophila melanogaster)
ren [plasma membrane]
(Xenopus tropicalis)
Homologues of REN(24-406) [plasma membrane]
(Caenorhabditis elegans)
Homologues of REN(24-406) [plasma membrane]
(Drosophila melanogaster)
Pgcl [plasma membrane]
(Drosophila melanogaster)
asp-8 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG17134 [plasma membrane]
(Drosophila melanogaster)
asp-19 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG17283 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG5863 [plasma membrane]
(Drosophila melanogaster)
asp-13 [plasma membrane]
(Caenorhabditis elegans)
asp-16 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG31926 [plasma membrane]
(Drosophila melanogaster)
asp-14 [plasma membrane]
(Caenorhabditis elegans)
asp-2 [plasma membrane]
(Caenorhabditis elegans)
Ren1 [plasma membrane]
(Mus musculus)
Ren1 [plasma membrane]
(Rattus norvegicus)
asp-17 [plasma membrane]
(Caenorhabditis elegans)
asp-5 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000528.1
ZINC - World Drugs
RENI_HUMAN
Guide to Pharmacology - Targets
2413
OpenTargets
ENSG00000143839
ENSEMBL
ENSP00000272190
,
ENST00000272190
ZINC - FDA approved
RENI_HUMAN
ZINC - Substances
RENI_HUMAN
ZINC - Biogenic
RENI_HUMAN
ZINC target
P00797
PRO
P00797
GlyGen
P00797
PDB
5T4S
,
2IL2
,
3G6Z
,
2G22
,
2G1O
,
3D91
,
2G1S
,
4XX4
,
2I4Q
,
3Q3T
,
4XX3
,
3VYF
,
1BIM
,
4AMT
,
4GJ5
,
3OQK
,
5TMK
,
2G1Y
,
2V0Z
,
5VRP
,
6I3F
,
3VCM
,
3SFC
,
2G27
,
4GJD
,
2BKS
,
2REN
,
5SY2
,
4GJ9
,
7XGK
,
3G72
,
3GW5
,
4PYV
,
5SXN
,
4GJA
,
5SZ9
,
3OAG
,
1BIL
,
5TMG
,
2V11
,
4RYC
,
3G70
,
4Q1N
,
7XGO
,
3Q4B
,
3OQF
,
3OAD
,
2X0B
,
3OOT
,
2G20
,
2IKO
,
3VUC
,
2G1R
,
2G21
,
2G24
,
3KM4
,
3VSX
,
1HRN
,
4GJ7
,
2FS4
,
2V16
,
5VPM
,
4GJ6
,
2IKU
,
2G1N
,
1BBS
,
3K1W
,
2G26
,
4S1G
,
2V12
,
5KOS
,
5V8V
,
3O9L
,
2BKT
,
1RNE
,
2V13
,
4GJB
,
3VYE
,
4RZ1
,
4GJ8
,
4RYG
,
5KOQ
,
3Q5H
,
5KOT
,
3VSW
,
4GJC
,
5SY3
,
3OWN
,
2V10
,
3VYD
,
7XGP
ZINC - Investigational
RENI_HUMAN
ZINC - Metabolites
RENI_HUMAN
IntEnz
3.4.23.15
HPA
ENSG00000143839-REN
Pharos - Targets
P00797
Orphanet
REN
ZINC - Predictions - Purchasable
RENI_HUMAN
HMDB Protein
HMDBP02624
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01019 AGT
7
AGT(36-41) [extracellular region]
(R-HSA-2022355)
AGT(35-41) [extracellular region]
(R-HSA-2022354)
AGT(34-40) [extracellular region]
(R-HSA-2022351)
AGT(34-42) [extracellular region]
(R-HSA-2022348)
AGT [extracellular region]
(R-HSA-1998759)
AGT(34-43) [extracellular region]
(R-HSA-2022346)
AGT(34-41) [extracellular region]
(R-HSA-374187)
0.558
2
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