CS is cleaved from its proteoglycan

Stable Identifier
R-HSA-2065233
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Chondroitin sulfate (CS) is hydrolysed from its chondroitin sulfate proteoglycan (CSPG) by an unknown human beta-xylosidase. The reaction shown here is based on studies of a rabbit lysosomal enzyme fraction assay (Takagaki et al. 1988). CSPG can have many CS chains attached to it; this example shows the hydrolysis of one CS chain from CSPG.

Literature References
PubMed ID Title Journal Year
3134052 Demonstration of an endo-beta-galactosidase and an endo-beta-xylosidase that degrade the proteoglycan linkage region

Takagaki, K, Nakamura, T, Endo, M

Biochim Biophys Acta 1988
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydrolase activity, acting on glycosyl bonds of beta-xylosidase [lysosomal lumen]
Physical Entity
Activity
Authored
Reviewed
Created