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C4S-BGN [lysosomal lumen]
Stable Identifier
R-HSA-2065070
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
_BGN, Biglycan, PGS1_HUMAN, BGN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
CS/DS degradation (Homo sapiens)
CS is cleaved from its proteoglycan (Homo sapiens)
CSPGs [lysosomal lumen] (Homo sapiens)
C4S-PG [lysosomal lumen] (Homo sapiens)
C4S-BGN [lysosomal lumen] (Homo sapiens)
DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)
CSPGs [lysosomal lumen] (Homo sapiens)
C4S-PG [lysosomal lumen] (Homo sapiens)
C4S-BGN [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21810 BGN
Gene Names
BGN, SLRR1A
Chain
signal peptide:1-16, propeptide:17-37, chain:38-368
Reference Genes
BioGPS Gene:633 BGN
COSMIC (genes):BGN BGN
CTD Gene:633 BGN
dbSNP Gene:633 BGN
ENSEMBL:ENSG00000182492 BGN
HGNC:1044 BGN
KEGG:hsa:633 BGN
Monarch:633 BGN
NCBI Gene:633 BGN
OMIM:301870 BGN
UCSC:P21810 BGN
Reference Transcript
RefSeq:NM_001711.5 BGN
RefSeq:XM_017029724.1 BGN
Other Identifiers
11721244_a_at
11721245_s_at
11721246_x_at
11749066_s_at
11751483_s_at
11751484_x_at
11752779_x_at
17108003
201261_PM_x_at
201261_x_at
201262_PM_s_at
201262_s_at
213905_PM_x_at
213905_x_at
38126_at
3995635
3995641
3995642
3995643
3995644
3995650
3995651
3995652
3995654
3995655
3995657
3995658
3995659
3995660
3995661
3995662
3995663
3995664
3995665
633
74989_at
8170648
89603_at
A_23_P34126
GE57511
GO:0005198
GO:0005201
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005796
GO:0005886
GO:0008150
GO:0009986
GO:0019955
GO:0030021
GO:0030133
GO:0030312
GO:0031012
GO:0031410
GO:0042383
GO:0043202
GO:0043226
GO:0048856
GO:0050840
GO:0060348
GO:0061975
GO:0062023
GO:0070062
HMNXSV003014010
Hs.821.1.A1_3p_a_at
ILMN_2206746
J04599_at
PH_hs_0000098
TC0X000750.hg
g12803216_3p_a_at
g4502402_3p_a_at
g4502402_3p_x_at
Participates
as a member of
C4S-PG [lysosomal lumen] (Homo sapiens)
Other forms of this molecule
XylS-BGN [Golgi lumen]
Gal-Xyl-BGN [Golgi lumen]
BGN [Golgi lumen]
Gal-Gal-Xyl-BGN [Golgi lumen]
GlcA-Gal-Gal-Xyl-BGN [Golgi lumen]
D2,4(S)2-BGN [Golgi lumen]
dermatan-BGN [Golgi lumen]
D4S-BGN [Golgi lumen]
D2,4,4(S)3-BGN [Golgi lumen]
chondroitin(3)-BGN [Golgi lumen]
C4S-BGN [Golgi lumen]
chondroitin(2)-BGN [Golgi lumen]
chondroitin(1)-BGN [Golgi lumen]
D2,4,4(S)3-BGN [extracellular region]
D2,4(S)2-BGN [extracellular region]
D4S-BGN [extracellular region]
C6S-BGN [Golgi lumen]
CSE-BGN [Golgi lumen]
C4S-BGN [extracellular region]
C6S-BGN [extracellular region]
CSE-BGN [extracellular region]
C6S-BGN [lysosomal lumen]
CSE-BGN [lysosomal lumen]
BGN [lysosomal lumen]
D4S-BGN [lysosomal lumen]
D2,4(S)2-BGN [lysosomal lumen]
D2,4,4(S)3-BGN [lysosomal lumen]
BGN [extracellular region]
Inferred To
Bgn [lysosomal lumen]
(Mus musculus)
Bgn [lysosomal lumen]
(Rattus norvegicus)
bgna [lysosomal lumen]
(Danio rerio)
Dmel\CG32055 [lysosomal lumen]
(Drosophila melanogaster)
BGN [lysosomal lumen]
(Bos taurus)
BGN [lysosomal lumen]
(Canis familiaris)
BGN [lysosomal lumen]
(Sus scrofa)
bgn [lysosomal lumen]
(Xenopus tropicalis)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63513) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
OpenTargets
ENSG00000182492
ENSEMBL
ENSP00000327336
,
ENST00000331595
HPA
ENSG00000182492-BGN
PRO
P21810
Pharos - Targets
P21810
Orphanet
BGN
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