WWTR1 (TAZ) binds RUNX2

Stable Identifier
R-HSA-2064932
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In the nucleus the WWTR1 (TAZ) transcriptional coactivator can bind the RUNX2 transcription factor to form a complex. This interaction has not been experimentally characterized in human cells but is inferred from properties of the homologous mouse proteins. The stoichiometry of this complex is unknown (Cui et al. 2003).

Formation of the RUNX2:WWTR1 complex is implicated in promotion of luminal breast cancer progression through regulation of E-cadherin (CDH1) and cross-talk with ERBB2 (HER2) signaling (Brusgard et al. 2015).

Literature References
PubMed ID Title Journal Year
12529404 Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ

Cui, CB, Cooper, LF, Yang, X, Karsenty, G, Aukhil, I

Mol Cell Biol 2003
16099986 TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

Hong, JH, Hwang, ES, McManus, MT, Amsterdam, A, Tian, Y, Kalmukova, R, Mueller, E, Benjamin, T, Spiegelman, BM, Sharp, PA, Hopkins, N, Yaffe, MB

Science 2005
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