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Gal-Xyl-BGN [Golgi lumen]
Stable Identifier
R-HSA-2064103
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
BGN, Biglycan, PGS1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective B3GALT6 causes EDSP2 and SEMDJL1 (Homo sapiens)
Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-BGN [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-BGN [Golgi lumen] (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-BGN [Golgi lumen] (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-BGN [Golgi lumen] (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Gal-Xyl-BGN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21810 BGN
Gene Names
BGN, SLRR1A
Chain
signal peptide:1-16, propeptide:17-37, chain:38-368
Reference Genes
BioGPS Gene:633 BGN
COSMIC (genes):BGN BGN
CTD Gene:633 BGN
dbSNP Gene:633 BGN
ENSEMBL:ENSG00000182492 BGN
ENSEMBL_homo_sapiens_GENE:ENSG00000182492.16 BGN
HGNC:1044 BGN
KEGG Gene (Homo sapiens):633 BGN
Monarch:633 BGN
NCBI Gene:633 BGN
OMIM:301870 BGN
UCSC:P21810 BGN
Reference Transcript
RefSeq:XM_017029724.1 BGN
RefSeq:NM_001711.5 BGN
Other Identifiers
11721244_a_at
11721245_s_at
11721246_x_at
11749066_s_at
11751483_s_at
11751484_x_at
11752779_x_at
17108003
201261_PM_x_at
201261_x_at
201262_PM_s_at
201262_s_at
213905_PM_x_at
213905_x_at
38126_at
3995635
3995641
3995642
3995643
3995644
3995650
3995651
3995654
3995655
3995657
3995658
3995659
3995660
3995661
3995662
3995663
3995664
3995665
633
74989_at
8170648
89603_at
A_23_P34126
GE57511
GO:0005198
GO:0005201
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0008150
GO:0009986
GO:0019955
GO:0030021
GO:0030133
GO:0030312
GO:0031012
GO:0031410
GO:0042383
GO:0043202
GO:0043226
GO:0048856
GO:0050840
GO:0060348
GO:0061975
GO:0062023
GO:0070062
HMNXSV003014010
Hs.821.1.A1_3p_a_at
ILMN_2206746
J04599_at
PH_hs_0000098
TC0X000750.hg
g12803216_3p_a_at
g4502402_3p_a_at
g4502402_3p_x_at
Participates
as a member of
Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
BGN [extracellular region]
dermatan-BGN [Golgi lumen]
D2,4(S)2-BGN [Golgi lumen]
D2,4,4(S)3-BGN [Golgi lumen]
D4S-BGN [Golgi lumen]
CSE-BGN [lysosomal lumen]
C6S-BGN [lysosomal lumen]
C4S-BGN [lysosomal lumen]
D2,4(S)2-BGN [lysosomal lumen]
D4S-BGN [lysosomal lumen]
D4S-BGN [extracellular region]
D2,4(S)2-BGN [extracellular region]
D2,4,4(S)3-BGN [extracellular region]
BGN [lysosomal lumen]
D2,4,4(S)3-BGN [lysosomal lumen]
CSE-BGN [extracellular region]
C6S-BGN [extracellular region]
Gal-Gal-Xyl-BGN [Golgi lumen]
GlcA-Gal-Gal-Xyl-BGN [Golgi lumen]
XylS-BGN [Golgi lumen]
BGN [Golgi lumen]
chondroitin(1)-BGN [Golgi lumen]
chondroitin(2)-BGN [Golgi lumen]
chondroitin(3)-BGN [Golgi lumen]
C4S-BGN [Golgi lumen]
C6S-BGN [Golgi lumen]
CSE-BGN [Golgi lumen]
C4S-BGN [extracellular region]
Inferred To
BGN [Golgi lumen]
(Bos taurus)
BGN [Golgi lumen]
(Canis familiaris)
BGN [Golgi lumen]
(Sus scrofa)
Bgn [Golgi lumen]
(Mus musculus)
Bgn [Golgi lumen]
(Rattus norvegicus)
bgn [Golgi lumen]
(Xenopus tropicalis)
Dmel\CG32055 [Golgi lumen]
(Drosophila melanogaster)
bgna [Golgi lumen]
(Danio rerio)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63502) at unknown position
Modification
beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001702.1
,
XP_016885213.1
OpenTargets
ENSG00000182492
GeneCards
P21810
HPA
ENSG00000182492-BGN
Ensembl
ENSP00000327336
,
ENSG00000182492
,
ENST00000331595
PRO
P21810
Pharos - Targets
P21810
Orphanet
23903
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