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FZD1 [plasma membrane]
Stable Identifier
R-HSA-205974
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Frizzled1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Frizzled receptors bind Wnts (Homo sapiens)
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
Frizzled receptors:WNTs [plasma membrane] (Homo sapiens)
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
DVL is recruited to the receptor (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT-dependent phosphorylation of DVL (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNTs bind the FZD receptor to initiate PCP pathway (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT:FZD [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
FZD recruits DVL to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
canonical FZD receptors [plasma membrane] (Homo sapiens)
FZD1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UP38 FZD1
Gene Names
FZD1
Chain
signal peptide:1-69, chain:70-647
Reference Genes
BioGPS Gene:8321 FZD1
COSMIC (genes):FZD1 FZD1
CTD Gene:8321 FZD1
dbSNP Gene:8321 FZD1
ENSEMBL:ENSG00000157240 FZD1
HGNC:4038 FZD1
KEGG Gene (Homo sapiens):8321 FZD1
Monarch:8321 FZD1
NCBI Gene:8321 FZD1
OMIM:603408 FZD1
UCSC:Q9UP38 FZD1
Reference Transcript
RefSeq:NM_003505.1 FZD1
Other Identifiers
0001740433
11739813_a_at
11739814_a_at
17048228
204451_at
204452_s_at
236035_at
3012225
3012226
3012227
3012228
3012229
3012230
3012231
3012232
3012233
3012234
3012235
3012236
3012237
3012238
3012239
3012245
3012246
38300_at
55873_at
8134117
8321
A_14_P119785
A_23_P134502
A_24_P38276
GE53425
GE828820
GO:0003674
GO:0004888
GO:0004930
GO:0005102
GO:0005109
GO:0005515
GO:0005575
GO:0005886
GO:0005925
GO:0007165
GO:0007166
GO:0007186
GO:0007267
GO:0007275
GO:0008150
GO:0009058
GO:0009986
GO:0010976
GO:0016020
GO:0016021
GO:0016055
GO:0017147
GO:0022607
GO:0030154
GO:0030165
GO:0030182
GO:0032991
GO:0034330
GO:0034641
GO:0035425
GO:0042493
GO:0042813
GO:0044338
GO:0044339
GO:0045893
GO:0048856
GO:0051091
GO:0060070
GO:0060071
GO:0099054
GO:1904886
GO:1904953
GO:1990909
HMNXSV003053347
Hs.65788.0.A1_3p_at
ILMN_1696546
ILMN_1784250
ILMN_2222065
ILMN_2234526
PH_hs_0005169
TC07000543.hg
g4503824_3p_at
g5305406_3p_a_at
Participates
as a component of
Wnt1:Frizzled1:phospho (3 sites) LRP6:CKIgamma [plasma membrane] (Homo sapiens)
Wnt1:Frizzled1:phospho LRP6:CKIgamma [plasma membrane] (Homo sapiens)
as a candidate of
Frizzled receptors [plasma membrane] (Homo sapiens)
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
as a member of
canonical FZD receptors [plasma membrane] (Homo sapiens)
PCP pathway FZDs [plasma membrane] (Homo sapiens)
Inferred To
Fzd1 [plasma membrane]
(Mus musculus)
Fzd1 [plasma membrane]
(Rattus norvegicus)
fz [plasma membrane]
(Drosophila melanogaster)
FZD1 [plasma membrane]
(Bos taurus)
FZD1 [plasma membrane]
(Canis familiaris)
FZD1 [plasma membrane]
(Gallus gallus)
FZD1 [plasma membrane]
(Sus scrofa)
fzd1 [plasma membrane]
(Danio rerio)
mom-5 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003496.1
Guide to Pharmacology - Targets
229
OpenTargets
ENSG00000157240
GeneCards
Q9UP38
HPA
ENSG00000157240-FZD1
Ensembl
ENSG00000157240
,
ENST00000287934
,
ENSP00000287934
PRO
Q9UP38
Pharos - Targets
Q9UP38
GlyGen
Q9UP38
HMDB Protein
HMDBP07697
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