Reactome | p-6S-APC-1 [cytosol]

p-6S-APC-1 [cytosol]

Stable Identifier

R-HSA-205944

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho (6 sites) APC

Icon

External Reference Information

External Reference

UniProt:P25054-1 APC

Gene Names

APC, DP2.5

Other Identifiers

11731561_a_at

11731562_s_at

11757692_s_at

16988021

1912_s_at

203525_PM_s_at

203525_s_at

203526_PM_s_at

203526_s_at

203527_PM_s_at

203527_s_at

215310_PM_at

215310_at

216933_3p_x_at

216933_PM_x_at

216933_x_at

2824209

2824210

2824211

2824212

2824213

2824217

2824218

2824219

2824220

2824224

2824225

2824230

2824232

2824233

2824239

2824242

2824243

2824244

2824245

2824248

2824250

2824253

2824256

2824257

2824258

2824260

2824266

2824267

2824268

2824269

2824270

2824271

2824272

2824273

2824274

2824275

2824276

2824277

2824279

2824281

2824283

2824285

324

35433_s_at

36182_at

8107330

A_14_P106747

A_14_P116796

A_14_P135872

A_23_P70213

A_33_P3408983

GE58061

GO:0000281

GO:0000776

GO:0000910

GO:0001708

GO:0003170

GO:0003203

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005881

GO:0005886

GO:0005912

GO:0005923

GO:0006974

GO:0007026

GO:0007094

GO:0007155

GO:0007389

GO:0007399

GO:0008013

GO:0008017

GO:0008092

GO:0008285

GO:0008286

GO:0016055

GO:0016328

GO:0016342

GO:0016477

GO:0019887

GO:0019901

GO:0030027

GO:0030163

GO:0030178

GO:0030335

GO:0030877

GO:0031274

GO:0031625

GO:0032587

GO:0032886

GO:0034330

GO:0042995

GO:0043065

GO:0043161

GO:0043226

GO:0043231

GO:0045295

GO:0045732

GO:0045736

GO:0048471

GO:0048856

GO:0048870

GO:0051010

GO:0051988

GO:0060632

GO:0065003

GO:0070161

GO:0070830

GO:0070840

GO:0071944

GO:0090090

GO:0098772

GO:0120162

GO:1902807

GO:1904781

GO:1990909

GO:2000134

HMNXSV003016363

Hs.167825.0.S1_3p_at

Hs.75081.0.S2_3p_a_at

Hs.75081.1.S1_3p_a_at

ILMN_1662668

M73548_at

M74088_s_at

PH_hs_0031313

TC05003398.hg

g182396_3p_a_at

g4557318_3p_a_at

Participates

as an output of

Human APC is finally phosphorylated by Murine GSK3beta (Homo sapiens)

Other forms of this molecule

p-5S-APC-1 [cytosol]

APC-1 [cytosol]

p-S1505-APC-1 [cytosol]

p-S1501,S1505-APC-1 [cytosol]

Modified Residues

Name

O-phospho-L-serine at 1501

Coordinate

1501

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1503

Coordinate

1503

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1504

Coordinate

1504

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1505

Coordinate

1505

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1507

Coordinate

1507

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1510

Coordinate

1510

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_000029.2, NP_001120982.1, NP_001120983.2

OpenTargets

ENSG00000134982

ENSEMBL

ENST00000509732, ENSP00000426541, ENST00000507379, ENSP00000257430, ENST00000512211, ENSP00000423224, ENST00000257430, ENSP00000423828, ENSP00000427089, ENST00000508376

HPA

ENSG00000134982-APC

PRO

P25054

Pharos - Targets

P25054

Orphanet

APC

GlyGen

P25054

PDB

3QHE, 1V18, 8X2Q, 4YJL, 1JPP, 2RQU, 3NMW, 3RL8, 3RL7, 7F7O, 1M5I, 3NMX, 1TH1, 3AU3, 8GSJ, 4YK6, 4YJE, 3NMZ, 1EMU, 4G69, 5IZ8, 5Z8H, 5IZ9, 5IZA, 7XTY, 3T7U, 5B6G, 1DEB, 1T08, 5IZ6, 7F6M

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.962	22
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.845	17
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.825	6
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.816	6
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.802	6
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.738	8
UniProt:Q5JTC6 AMER1	5	AMER1 R497* [cytosol] (R-HSA-9663943) AMER1 S210* [cytosol] (R-HSA-5251492) AMER1 R358* [cytosol] (R-HSA-4839640) AMER1 R353* [cytosol] (R-HSA-9663939) AMER1 [cytosol] (R-HSA-1504189)	0.723	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.697	5
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.669	4
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.668	9
UniProt:Q96N96 SPATA13	1	SPATA13 [cytosol] (R-HSA-9690931)	0.667	5
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.667	4
UniProt:Q9NR80-3 ARHGEF4			0.646	5
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.64	3
UniProt:P14923 JUP	6	JUP [plasma membrane] (R-HSA-437260) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [cornified envelope] (R-HSA-8847739) JUP [cytosol] (R-HSA-201598)	0.64	3
UniProt:Q8N944 AMER3			0.631	8
UniProt:Q02248 Ctnnb1	14	Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) Ctnnb1 [nucleoplasm] (R-MMU-9735212) Ctnnb1 [plasma membrane] (R-MMU-9038440) Ctnnb1 [plasma membrane] (R-MMU-9761458) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363) phospho-Ctnnb1 [cytosol] (R-MMU-3134933) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926)	0.623	8
UniProt:O14640 DVL1	4	ub-DVL1 [cytosol] (R-HSA-4641157) DVL1 [cytosol] (R-HSA-201687) p-S-DVL1 [cytosol] (R-HSA-201700) pp-DVL1 [cytosol] (R-HSA-3772396)	0.623	6
UniProt:Q12959 DLG1	4	DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [cytosol] (R-HSA-416332) DLG1 [plasma membrane] (R-HSA-375977)	0.623	2
UniProt:Q96N96-1 SPATA13			0.619	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.615	3
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.59	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.564	2
UniProt:Q14114 LRP8	2	p-Y-LRP8 [plasma membrane] (R-HSA-432136) LRP8 [plasma membrane] (R-HSA-432113)	0.558	2
UniProt:Q86T90 K1328			0.547	2
UniProt:O14513 NCKP5			0.547	2
UniProt:Q04695 KRT17	1	KRT17 [cytosol] (R-HSA-201583)	0.547	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	2
UniProt:Q16204 CCDC6			0.527	4
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:Q9UI47 CTNA3			0.527	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.527	3
IntAct:EBI-6876712 CTNB1			0.499	6

Cite Us!