Interaction of APS and p-KIT

Stable Identifier
R-HSA-205319
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of APS and p-KIT
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

APS adapter protein has been identified as a KIT binding partner using yeast two-hybrid screening. APS contains a PH domain and an SH2 domain. The SH2 domain interacts with c-Kit phosphotyrosine residues Y568 and Y936 (Wollberg et al. 2003).

Literature References
PubMed ID Title Journal Year
12444928 The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit

Wollberg, P, Yoshimura, A, Gottfridsson, E, Lennartsson, J, Rönnstrand, L

Biochem J 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
Interaction of APS and p-KIT (Canis familiaris)
Interaction of APS and p-KIT (Danio rerio)
Interaction of APS and p-KIT (Mus musculus)
Interaction of APS and p-KIT (Rattus norvegicus)
Interaction of APS and p-KIT (Sus scrofa)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2007-12-10)
Cite Us!