Dimerization of KIT upon SCF binding

Stable Identifier
R-HSA-205231
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of the SCF dimer to KIT rapidly triggers KIT dimerization and autophosphorylation. It is thought that one SCF dimer binds simultaneously to two KIT monomers. The fourth Ig-like domain of KIT contains the dimerisation site; deletion of this domain completely abolishes KIT dimerisation and subsequent downstream signaling (Edling et al. 2007, Blechman et al. 1995). KIT dimerization is a crucial initial step in the SCF signal transduction process.

Literature References
PubMed ID Title Journal Year
9446650 Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer

Broudy, VC, Lin, NL, Bühring, HJ, Komatsu, N, Kavanagh, TJ

Blood 1998
8636116 Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit

Philo, JS, Wen, J, Wypych, J, Schwartz, MG, Mendiaz, EA, Langley, KE

J Biol Chem 1996
9045650 Kit receptor dimerization is driven by bivalent binding of stem cell factor

Lemmon, MA, Pinchasi, D, Zhou, M, Lax, I, Schlessinger, J

J Biol Chem 1997
17255936 Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases

Liu, H, Chen, X, Focia, PJ, He, X

EMBO J 2007
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