Binding of the SCF dimer to KIT rapidly triggers KIT dimerization and autophosphorylation. It is thought that one SCF dimer binds simultaneously to two KIT monomers. The fourth Ig-like domain of KIT contains the dimerisation site; deletion of this domain completely abolishes KIT dimerisation and subsequent downstream signaling (Edling et al. 2007, Blechman et al. 1995). KIT dimerization is a crucial initial step in the SCF signal transduction process.
Wypych, J, Schwartz, MG, Langley, KE, Wen, J, Mendiaz, EA, Philo, JS
Kavanagh, TJ, Komatsu, N, Bühring, HJ, Broudy, VC, Lin, NL
Schlessinger, J, Pinchasi, D, Zhou, M, Lax, I, Lemmon, MA
Liu, H, Chen, X, He, X, Focia, PJ
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