Reactome | HDAC2 [nucleoplasm]

HDAC2 [nucleoplasm]

Stable Identifier

R-HSA-205135

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HDA2_HUMAN, Histone deacetylase 2

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Locations in the PathwayBrowser for interactor UniProt:Q9C0K0 BC11B

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of chromatin organization proteins (Homo sapiens)
        
        SUMOylation of HDAC2 with SUMO1 (Homo sapiens)
        
        HDAC2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92769 HDAC2

Gene Names

HDAC2

Chain

chain:1-488

Reference Genes

BioGPS Gene:3066 HDAC2

COSMIC (genes):HDAC2 HDAC2

CTD Gene:3066 HDAC2

dbSNP Gene:3066 HDAC2

ENSEMBL:ENSG00000196591 HDAC2

ENSEMBL_homo_sapiens_GENE:ENSG00000196591.12 HDAC2

HGNC:4853 HDAC2

KEGG Gene (Homo sapiens):3066 HDAC2

Monarch:3066 HDAC2

NCBI Gene:3066 HDAC2

OMIM:605164 HDAC2

UCSC:Q92769 HDAC2

Reference Transcript

Other Identifiers

11727379_at

11754781_a_at

201833_PM_at

201833_at

242141_PM_at

242141_at

2970534

2970535

2970536

2970537

2970538

2970539

2970540

2970541

2970542

2970543

2970544

2970545

2970546

2970548

2970549

2970550

2970551

2970552

2970553

2970556

2970557

2970562

2970566

2970567

2970571

2970573

2970575

2970577

2970578

2970579

2970580

2970581

2970582

2970583

3066

34368_at

8129045

A_23_P122304

A_33_P3309924

GE81034

GE860085

GO:0000118

GO:0000122

GO:0000228

GO:0000781

GO:0000785

GO:0001975

GO:0003012

GO:0003300

GO:0003677

GO:0003682

GO:0003723

GO:0003824

GO:0004407

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0008284

GO:0009410

GO:0009913

GO:0010718

GO:0010944

GO:0010977

GO:0012501

GO:0016358

GO:0016575

GO:0016581

GO:0016787

GO:0019213

GO:0019899

GO:0022414

GO:0023052

GO:0030154

GO:0030336

GO:0030512

GO:0031000

GO:0031072

GO:0031492

GO:0031507

GO:0032496

GO:0032732

GO:0032760

GO:0032922

GO:0032967

GO:0032991

GO:0033558

GO:0034605

GO:0035094

GO:0035098

GO:0036211

GO:0042220

GO:0042393

GO:0042475

GO:0042531

GO:0042659

GO:0042733

GO:0042826

GO:0043066

GO:0043226

GO:0043433

GO:0045347

GO:0045862

GO:0045892

GO:0045893

GO:0045944

GO:0048149

GO:0048511

GO:0048714

GO:0048856

GO:0048870

GO:0051059

GO:0055093

GO:0060789

GO:0061000

GO:0061029

GO:0061198

GO:0061629

GO:0070301

GO:0070822

GO:0071300

GO:0071560

GO:0140096

GO:0140297

GO:0160008

GO:0160009

GO:0160010

GO:1902437

GO:1902455

GO:1902459

GO:1903351

GO:1904645

GO:1990841

GO:2000273

GO:2000736

GO:2000757

HMNXSV003001184

Hs.232662.0.A1_3p_at

Hs.232662.0.A1_3p_x_at

ILMN_1767747

PH_hs_0000406

TC06002035.hg

TC06003812.hg

U31814_at

g4557640_3p_at

Participates

as an input of

as a component of

as a member of

Histone deacetylase [nucleoplasm] (Homo sapiens)

as a candidate of

HDAC [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K462-HDAC2 [nucleoplasm]

Inferred To

Homologues of HDAC2 [nucleoplasm] (Caenorhabditis elegans)

hda-1 [nucleoplasm] (Caenorhabditis elegans)

clr6 [nucleoplasm] (Schizosaccharomyces pombe)

HDAC1 [nucleoplasm] (Drosophila melanogaster)

Hdac2 [nucleoplasm] (Mus musculus)

Hdac2 [nucleoplasm] (Rattus norvegicus)

RPD3 [nucleoplasm] (Saccharomyces cerevisiae)

HDAC2 [nucleoplasm] (Bos taurus)

HDAC2 [nucleoplasm] (Caenorhabditis elegans)

HDAC2 [nucleoplasm] (Canis familiaris)

HDAC2 [nucleoplasm] (Dictyostelium discoideum)

HDAC2 [nucleoplasm] (Gallus gallus)

HDAC2 [nucleoplasm] (Plasmodium falciparum)

HDAC2 [nucleoplasm] (Sus scrofa)

HDAC2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_011534090.1, NP_001518.3, XP_016866288.1

ZINC - World Drugs

HDAC2_HUMAN

Guide to Pharmacology - Targets

2616

OpenTargets

ENSG00000196591

ZINC - FDA approved

HDAC2_HUMAN

ZINC - Substances

HDAC2_HUMAN

ZINC - Biogenic

HDAC2_HUMAN

ZINC target

Q92769

PRO

Q92769

PDB

8C60, 7MOY, 7ZZS, 6XDM, 7ZZR, 8A0B, 7MOX, 6WI3, 6WHZ, 7ZZP, 8BPC, 7LTL, 7MOT, 8BPB, 7LTK, 7KBH, 6G3O, 3MAX, 6WHQ, 7MOS, 7ZZO, 6XEC, 8BPA, 7KBG, 5IX0, 6WHO, 7LTG, 6WBZ, 7JS8, 4LXZ, 7ZZW, 6WBW, 6XEB, 7ZZU, 5IWG, 6WHN, 4LY1, 7MOZ, 7ZZT

ZINC - Investigational

HDAC2_HUMAN

ZINC - Metabolites

HDAC2_HUMAN

GeneCards

Q92769

HPA

ENSG00000196591-HDAC2

Ensembl

ENSP00000430008, ENSP00000430432, ENST00000368632, ENSG00000196591, ENST00000519108, ENST00000519065, ENSP00000357621

Pharos - Targets

Q92769

ZINC - Predictions - Purchasable

HDAC2_HUMAN

HMDB Protein

HMDBP09107

Interactors (88)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.946	21
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.886	7
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.878	7
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.877	9
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.837	9
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.837	8
UniProt:Q9NP66 HM20A			0.837	7
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.837	6
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.837	7
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.837	7
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.812	6
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.788	5
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.788	6
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.788	5
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.788	8
UniProt:Q6PJG2 MDEAS			0.788	5
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.788	5
UniProt:Q8N108 MIER1			0.725	4
UniProt:Q14687 GSE1			0.725	4
UniProt:O14519 CDKA1			0.725	5
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.725	4
UniProt:Q9P2K3 RCOR3			0.725	4
UniProt:Q9P0W2 HMG20B	1	HMG20B [nucleoplasm] (R-HSA-996745)	0.725	5
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.725	5
UniProt:Q9Y232 CDYL			0.725	5
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.723	4
UniProt:Q9C0K0 BC11B			0.695	5
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.69	8
UniProt:Q92618 ZN516			0.662	7
UniProt:Q96BD5 PHF21A	1	PHF21A [nucleoplasm] (R-HSA-996754)	0.643	3
UniProt:Q92766 RREB1			0.643	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.643	3
UniProt:Q8N344 MIER2			0.643	4
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.643	3
UniProt:Q8IZ40 RCOR2			0.643	3
UniProt:Q9NP50 SHCAF			0.643	3
UniProt:Q9H0E3 SAP130	1	SAP130 [nucleoplasm] (R-HSA-3006732)	0.643	3
UniProt:Q6PH81 CP087			0.643	4
UniProt:Q9H147 TDIF1			0.643	4
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	4
UniProt:Q7Z3K6 MIER3			0.643	3
UniProt:Q9H7L9 SUDS3	2	K63polyUb-SUDS3 [nucleoplasm] (R-HSA-6782790) SUDS3 [nucleoplasm] (R-HSA-351696)	0.643	3
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.643	9
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.597	5
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.59	3
UniProt:P0DTD1-PRO_0000449623 REP			0.589	2
UniProt:Q9HD15 SRA1			0.589	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:Q2HR82 KBZIP			0.537	7
UniProt:Q8N5A5 ZGPAT			0.532	3
UniProt:O95785 WIZ			0.527	2
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.527	2
UniProt:P37275 ZEB1	1	ZEB1 [nucleoplasm] (R-HSA-6789836)	0.527	2
UniProt:Q14865 ARID5B	1	ARID5B [nucleoplasm] (R-HSA-5423050)	0.527	2
UniProt:Q9HAJ7 SAP30L	1	SAP30L [nucleoplasm] (R-HSA-351698)	0.527	2
UniProt:Q9H165 BCL11A	2	BCL11A(1-219)insDHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9713444) BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713447)	0.527	2
UniProt:Q8WWY6 MB3L1			0.527	3
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.527	2
UniProt:Q9P2Y4 ZN219			0.527	4
UniProt:Q4LE39 ARID4B	1	ARID4B [nucleoplasm] (R-HSA-2976647)	0.527	2
UniProt:Q9ULU4 ZMYD8			0.527	2
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.527	2
UniProt:O95567 CV031			0.527	2
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	3
UniProt:Q9UHF7 TRPS1			0.527	2
UniProt:O75956 CDKA2			0.527	2
UniProt:Q14202 ZMYM3			0.527	2
UniProt:O75362 ZNF217	1	ZNF217 [nucleoplasm] (R-HSA-9011738)	0.527	2
UniProt:Q9UK53 ING1			0.527	3
UniProt:Q9H160 ING2	2	monoSUMO1-K195-ING2 [nucleoplasm] (R-HSA-4086075) ING2 [nucleoplasm] (R-HSA-3215167)	0.527	3
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.527	2
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.527	3
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.527	2
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.525	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.524	3
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.524	2
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.524	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.508	2
UniProt:Q17R98 ZN827			0.499	2
UniProt:Q9H3M7 TXNIP	2	TXNIP [cytosol] (R-HSA-1250246) TXNIP [nucleoplasm] (R-HSA-9617747)	0.499	3
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.499	2
UniProt:P48382 RFX5			0.499	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:Q9BSJ6 PIMRE			0.462	2
UniProt:A2A935 Prdm16	2	Prdm16 [nucleoplasm] (R-MMU-9854760) Prdm16 [cytosol] (R-MMU-5634812)	0.462	2
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.462	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.462	4

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