TRAF6 attaches a lysine 63-linked polyubiquitin chain to lysine 19 of NRIF. Mutation of NRIF lysine 19 prevents p75-mediated apoptosis. p75NTR cleavage by gamma-secretase is required for NRIF ubiquitination.
Geetha, T, Kenchappa, RS, Wooten, MW, Carter, BD
© 2021 Reactome