TRAF6 attaches a lysine 63-linked polyubiquitin chain to lysine 19 of NRIF. Mutation of NRIF lysine 19 prevents p75-mediated apoptosis. p75NTR cleavage by gamma-secretase is required for NRIF ubiquitination.
Kenchappa, RS, Carter, BD, Wooten, MW, Geetha, T
ubiquitin-protein transferase activity of TRAF6 homotrimer [cytosol]
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