TRAF6 polyubiquitinates NRIF

Stable Identifier
R-HSA-205118
Type
Reaction
Species
Homo sapiens
Compartment
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TRAF6 attaches a lysine 63-linked polyubiquitin chain to lysine 19 of NRIF. Mutation of NRIF lysine 19 prevents p75-mediated apoptosis. p75NTR cleavage by gamma-secretase is required for NRIF ubiquitination.

Literature References
PubMed ID Title Journal Year
16252010 TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor

Kenchappa, RS, Carter, BD, Wooten, MW, Geetha, T

EMBO J 2005
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of TRAF6 homotrimer [cytosol]

Orthologous Events
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