TRAF6 polyubiquitinates NRIF

Stable Identifier
R-HSA-205118
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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TRAF6 polyubiquitinates NRIF
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TRAF6 attaches a lysine 63-linked polyubiquitin chain to lysine 19 of NRIF. Mutation of NRIF lysine 19 prevents p75-mediated apoptosis. p75NTR cleavage by gamma-secretase is required for NRIF ubiquitination.
Literature References
PubMed ID Title Journal Year
16252010 TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor

Geetha, T, Kenchappa, RS, Wooten, MW, Carter, BD

EMBO J 2005
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of TRAF6 homotrimer [cytosol]

Physical Entity
TRAF6 homotrimer [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
TRAF6 polyubiquitinates NRIF (Bos taurus)
TRAF6 polyubiquitinates NRIF (Canis familiaris)
TRAF6 polyubiquitinates NRIF (Gallus gallus)
TRAF6 polyubiquitinates NRIF (Mus musculus)
TRAF6 polyubiquitinates NRIF (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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