TRAF6 polyubiquitinates NRIF

Stable Identifier
R-HSA-205118
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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TRAF6 polyubiquitinates NRIF
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TRAF6 attaches a lysine 63-linked polyubiquitin chain to lysine 19 of NRIF. Mutation of NRIF lysine 19 prevents p75-mediated apoptosis. p75NTR cleavage by gamma-secretase is required for NRIF ubiquitination.

Literature References
PubMed ID Title Journal Year
16252010 TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor

Kenchappa, RS, Carter, BD, Wooten, MW, Geetha, T

EMBO J 2005
Participants
Input
Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of TRAF6 homotrimer [cytosol]

Physical Entity
TRAF6 homotrimer [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
TRAF6 polyubiquitinates NRIF (Bos taurus)
TRAF6 polyubiquitinates NRIF (Canis familiaris)
TRAF6 polyubiquitinates NRIF (Danio rerio)
TRAF6 polyubiquitinates NRIF (Gallus gallus)
TRAF6 polyubiquitinates NRIF (Mus musculus)
TRAF6 polyubiquitinates NRIF (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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