Once bound to the NGF:p75NTR complex, NADE contributes to cell death signalling by promoting activation of caspases 2 and 3. It is unclear whether JNK activation is involved. The apoptotic function of NADE was observed in oligodendrocytes (Mukai et al. 2002).
cysteine-type endopeptidase activator activity involved in apoptotic process of NGF:p75NTR:NADE [plasma membrane]