p75NTR:NADE promotes caspase2/3 activation

Stable Identifier
R-HSA-205117
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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p75NTR:NADE promotes caspase2/3 activation
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Once bound to the NGF:p75NTR complex, NADE contributes to cell death signalling by promoting activation of caspases 2 and 3. It is unclear whether JNK activation is involved. The apoptotic function of NADE was observed in oligodendrocytes (Mukai et al. 2002).
Literature References
PubMed ID Title Journal Year
11830582 Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis

Mukai, J, Shoji, S, Kimura, MT, Okubo, S, Sano, H, Suvanto, P, Li, Y, Irie, S, Sato, TA

J Biol Chem 2002
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Catalyst Activity

cysteine-type endopeptidase activator activity involved in apoptotic process of NGF:p75NTR:NADE [plasma membrane]

Physical Entity
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
Activity
cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656)
Orthologous Events
p75NTR:NADE promotes caspase2/3 activation (Bos taurus)
p75NTR:NADE promotes caspase2/3 activation (Canis familiaris)
p75NTR:NADE promotes caspase2/3 activation (Mus musculus)
p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)
p75NTR:NADE promotes caspase2/3 activation (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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