NFG and proNGF binds to p75NTR

Stable Identifier
R-HSA-205017
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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NFG and proNGF binds to p75NTR
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When the co-receptor sortilin is present at the cell surface, proNGF preferentially interacts with a p75NTR:sortilin complex. Thus, proNGF, which does not bind TRKA, discriminates between TRKA and p75NTR, in cells that express both receptors. The same is true for proBDNF. Pro-neurotrophin binding to p75NTR:sortilin activates an apoptotic cascade, which may be involved in cell death after injury, and in neurodegenerative diseases such as Alzheimer's dementia.
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Events
Participates
as an event of
Event Information
Go Biological Process
neurotrophin TRK receptor signaling pathway (0048011)
Orthologous Events
NFG and proNGF binds to p75NTR (Bos taurus)
NFG and proNGF binds to p75NTR (Canis familiaris)
NFG and proNGF binds to p75NTR (Danio rerio)
NFG and proNGF binds to p75NTR (Gallus gallus)
NFG and proNGF binds to p75NTR (Mus musculus)
NFG and proNGF binds to p75NTR (Rattus norvegicus)
NFG and proNGF binds to p75NTR (Sus scrofa)
NFG and proNGF binds to p75NTR (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)
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