Polyubiquitinated NRIF migrates to the nucleus

Stable Identifier
R-HSA-204947
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NRIF polyubiquitination is necessary for nuclear translocation. The carboxyl terminus of NRIF mediates nuclear localization, whereas the amino terminus prevents it. Once in the nucleus, NRIF regulates gene expression, acting as a transcriptional repressor.

Literature References
PubMed ID Title Journal Year
16630834 Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons

Kenchappa, RS, Zampieri, N, Chao, MV, Barker, PA, Teng, HK, Hempstead, BL, Carter, BD

Neuron 2006
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