Polyubiquitinated NRIF migrates to the nucleus

Stable Identifier
R-HSA-204947
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Polyubiquitinated NRIF migrates to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NRIF polyubiquitination is necessary for nuclear translocation. The carboxyl terminus of NRIF mediates nuclear localization, whereas the amino terminus prevents it. Once in the nucleus, NRIF regulates gene expression, acting as a transcriptional repressor.

Literature References
PubMed ID Title Journal Year
16630834 Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons

Kenchappa, RS, Zampieri, N, Chao, MV, Barker, PA, Teng, HK, Hempstead, BL, Carter, BD

Neuron 2006
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Polyubiquitinated NRIF migrates to the nucleus (Bos taurus)
Polyubiquitinated NRIF migrates to the nucleus (Canis familiaris)
Polyubiquitinated NRIF migrates to the nucleus (Danio rerio)
Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)
Polyubiquitinated NRIF migrates to the nucleus (Mus musculus)
Polyubiquitinated NRIF migrates to the nucleus (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-06)