NRIF polyubiquitination is necessary for nuclear translocation. The carboxyl terminus of NRIF mediates nuclear localization, whereas the amino terminus prevents it. Once in the nucleus, NRIF regulates gene expression, acting as a transcriptional repressor.
Kenchappa, RS, Carter, BD, Zampieri, N, Hempstead, BL, Barker, PA, Teng, HK, Chao, MV
© 2023 Reactome