ST3GAL1-4,6 optionally cap keratan chain

Stable Identifier
R-HSA-2046285
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
Synonyms
The keratan chain can be capped by N-acetylneuraminic acid
ReviewStatus
5/5
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ST3GAL1-4,6 optionally cap keratan chain
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The human genes ST3GAL1-4 and 6 encode for sialyltransferase1-4 and 6 respectively (Shang et al. 1999, Kim et al. 1996, Kitagawa and Paulson, 1993, Basu et al. 1993, Okajima et al. 1999). They add a sialyl residue to the growing keratan chain, blocking any further chain elongation.
Literature References
PubMed ID Title Journal Year
8920913 Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II)

Kim, YJ, Kim, KS, Kim, SH, Kim, CH, Ko, JH, Choe, IS, Tsuji, S, Lee, YC

Biochem Biophys Res Commun 1996
8611500 Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line

Basu, SS, Basu, M, Li, Z, Basu, S

Biochemistry 1996
10206952 Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids

Okajima, T, Fukumoto, S, Miyazaki, H, Ishida, H, Kiso, M, Furukawa, K, Furukawa, K, Urano, T

J Biol Chem 1999
8333853 Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase

Kitagawa, H, Paulson, JC

Biochem Biophys Res Commun 1993
10504389 Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver

Shang, J, Qiu, R, Wang, J, Liu, J, Zhou, R, Ding, H, Yang, S, Zhang, S, Jin, C

Eur J Biochem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL1-4,6 [Golgi membrane]

Physical Entity
ST3GAL1-4,6 [Golgi membrane] (Homo sapiens)
Activity
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity (GO:0003836)
Orthologous Events
ST3GAL1-4,6 optionally cap keratan chain (Bos taurus)
ST3GAL1-4,6 optionally cap keratan chain (Canis familiaris)
ST3GAL1-4,6 optionally cap keratan chain (Danio rerio)
ST3GAL1-4,6 optionally cap keratan chain (Gallus gallus)
ST3GAL1-4,6 optionally cap keratan chain (Mus musculus)
ST3GAL1-4,6 optionally cap keratan chain (Rattus norvegicus)
ST3GAL1-4,6 optionally cap keratan chain (Sus scrofa)
ST3GAL1-4,6 optionally cap keratan chain (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2011-12-01)
Reviewed
D'Eustachio, P  (2012-03-28)
D'Eustachio, P  (2025-03-12)
Created
Jassal, B  (2012-01-11)
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