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Extracellular KSPG translocates to the lysosome for degradation
Stable Identifier
R-HSA-2046239
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
,
lysosomal lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Keratan sulfate/keratin metabolism (Homo sapiens)
Keratan sulfate degradation (Homo sapiens)
Extracellular KSPG translocates to the lysosome for degradation (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
As part of the natural turnover of GAGs, extracellular KSPGs translocate to the lysosome to be degraded. The translocation process is unsure but could be either endocytosis from outside the cell or autophagy from inside the cell (Winchester 2005).
Literature References
PubMed ID
Title
Journal
Year
15647514
Lysosomal metabolism of glycoproteins
Winchester, B
Glycobiology
2005
Participants
Input
KSPG(2) [extracellular region]
(Homo sapiens)
Output
KSPG(2) [lysosomal lumen]
(Homo sapiens)
Participates
as an event of
Keratan sulfate degradation (Homo sapiens)
Event Information
Go Biological Process
endocytosis (0006897)
Orthologous Events
Extracellular KSPG translocates to the lysosome for degradation (Bos taurus)
Extracellular KSPG translocates to the lysosome for degradation (Canis familiaris)
Extracellular KSPG translocates to the lysosome for degradation (Danio rerio)
Extracellular KSPG translocates to the lysosome for degradation (Drosophila melanogaster)
Extracellular KSPG translocates to the lysosome for degradation (Gallus gallus)
Extracellular KSPG translocates to the lysosome for degradation (Mus musculus)
Extracellular KSPG translocates to the lysosome for degradation (Rattus norvegicus)
Extracellular KSPG translocates to the lysosome for degradation (Sus scrofa)
Extracellular KSPG translocates to the lysosome for degradation (Xenopus tropicalis)
Authored
Jassal, B (2012-01-11)
Reviewed
Hill, DP (2022-05-20)
D'Eustachio, P (2012-03-28)
Created
Jassal, B (2012-01-11)
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