Extracellular KSPG translocates to the lysosome for degradation

Stable Identifier
R-HSA-2046239
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, lysosomal lumen
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Extracellular KSPG translocates to the lysosome for degradation
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As part of the natural turnover of GAGs, extracellular KSPGs translocate to the lysosome to be degraded. The translocation process is unsure but could be either endocytosis from outside the cell or autophagy from inside the cell (Winchester 2005).

Literature References
PubMed ID Title Journal Year
15647514 Lysosomal metabolism of glycoproteins

Winchester, B

Glycobiology 2005
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Orthologous Events
Extracellular KSPG translocates to the lysosome for degradation (Bos taurus)
Extracellular KSPG translocates to the lysosome for degradation (Canis familiaris)
Extracellular KSPG translocates to the lysosome for degradation (Danio rerio)
Extracellular KSPG translocates to the lysosome for degradation (Drosophila melanogaster)
Extracellular KSPG translocates to the lysosome for degradation (Gallus gallus)
Extracellular KSPG translocates to the lysosome for degradation (Mus musculus)
Extracellular KSPG translocates to the lysosome for degradation (Rattus norvegicus)
Extracellular KSPG translocates to the lysosome for degradation (Sus scrofa)
Extracellular KSPG translocates to the lysosome for degradation (Xenopus tropicalis)
Authored
Jassal, B  (2012-01-11)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2012-01-11)