Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA

Stable Identifier
R-HSA-2046097
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Tetracosatetraenoyl-CoA is further desaturated by delta 6-desaturase (FADS2) to tetracosapentaenoyl-CoA (TPA-CoA, 6,9,12,15,18-24:5(n-6)).
Literature References
PubMed ID Title Journal Year
1834642 The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase

Sankarappa, S, Reinhart, M, Sprecher, H, Voss, A

J Biol Chem 1991
11988075 The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis

Jan, S, d'Andréa, S, Catheline, D, Bouriel, M, Thibault, JN, Legrand, P, Rioux, V, Guillou, H

Biochem J 2002
Participants
Participates
Catalyst Activity

linoleoyl-CoA desaturase activity of FADS2 [endoplasmic reticulum membrane]

Orthologous Events
Authored
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