Reactome | Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA

Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA

Stable Identifier

R-HSA-2046097

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA

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Tetracosatetraenoyl-CoA is further desaturated by delta 6-desaturase (FADS2) to tetracosapentaenoyl-CoA (TPA-CoA, 6,9,12,15,18-24:5(n-6)).

Literature References

PubMed ID	Title	Journal	Year
1834642	The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase Voss, A, Reinhart, M, Sankarappa, S, Sprecher, H	J Biol Chem	1991
11988075	The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis d'Andréa, S, Guillou, H, Jan, S, Catheline, D, Thibault, JN, Bouriel, M, Rioux, V, Legrand, P	Biochem J	2002