Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA

Stable Identifier
R-HSA-2046094
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Gamma-linolenoyl-CoA (6,9,12-20:3(n-6)) is rapidly elongated to dihomo-gamma-linolenoyl-CoA (DGL-CoA; 8,11,14-20:3(n-6)) by the action of C18-PUFA-specific elongase 5 (ELOVL5). Two carbon atoms are added during this reaction. DGL-CoA later undergoes desaturation to form arachidonic acid (AA, 5,8,11,14-20:4(n-6)).
Depending on the cell type, DGL-CoA can also be metabolized by cyclooxygenases and lipoxygenases to produce anti-inflammatory eicosanoids (prostaglandins of series 1 (PGE1) and 15-hydroxyeico- satrienoic acid (15-HETrE)). GLA and these two oxidative metabolites exert clinical effects in a variety of diseases, including suppression of chronic inflammation, vasodilation and lowering of blood pressure, inhibition of platelet aggregation and thrombosis. (Fan et al. 2001, Fan & Chapkin 1998, Kapoor & Huang. 2006)
Literature References
PubMed ID Title Journal Year
9732298 Importance of dietary gamma-linolenic acid in human health and nutrition

Fan, YY, Chapkin, RS

J Nutr 1998
8609415 Metabolism of gammalinolenic acid in human neutrophils

Chilton, FH, Fonteh, AN, Swan, DD, Surette, ME, Chilton-Lopez, T, Johnson, MM

J Immunol 1996
10970790 Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids

Huang, YS, Bobik, EG, Parker-Barnes, JM, Dorado, J, Chuang, LT, Das, T, Kroeger, PE, Mukerji, P, Leonard, AE, Thurmond, JM

Biochem J 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]

Physical Entity
ELOVL1,2,3,5 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
fatty acid elongase activity (GO:0009922)
Orthologous Events
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Bos taurus)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Caenorhabditis elegans)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Canis familiaris)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Danio rerio)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Dictyostelium discoideum)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Drosophila melanogaster)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Gallus gallus)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Mus musculus)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Plasmodium falciparum)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Rattus norvegicus)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Saccharomyces cerevisiae)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Schizosaccharomyces pombe)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Sus scrofa)
Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Xenopus tropicalis)
Authored
Garapati, P V  (2012-01-11)
Created
Garapati, P V  (2012-01-11)
Cite Us!