Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA

Stable Identifier
Reaction [transition]
Homo sapiens
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Eicosatetraenoyl-CoA (ETA-CoA) is desaturated by an additional carbon-carbon bond to form 5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-CoA (EPA-CoA, 5,8,11,14,17-20:5(n-3)). Delta-5-desaturase is required for this conversion. EPA-CoA has health benefits due to its anti-inflammatory actions. It is a precursor for the anti-inflammatory series-3 prostaglandins (PG), the series-5 leukotrienes (LT) and the series-3 thromboxanes (TA), which are anti-atherogenic and anti-thrombogenic (Ross et al. 2009).

Literature References
PubMed ID Title Journal Year
10601301 Cloning, expression, and fatty acid regulation of the human delta-5 desaturase

Cho, HP, Nakamura, M, Clarke, SD

J Biol Chem 1999
8096621 Comparison of the metabolism of alpha-linolenic acid and its delta 6 desaturation product, stearidonic acid, in cultured NIH-3T3 cells

Cantrill, RC, Huang, YS, Ells, GW, Horrobin, DF

Lipids 1993
Catalyst Activity

omega-6 fatty acid desaturase activity of FADS1 [endoplasmic reticulum membrane]

Orthologous Events
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