Reactome | Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA

Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA

Stable Identifier

R-HSA-2046089

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA

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Eicosatetraenoyl-CoA (ETA-CoA) is desaturated by an additional carbon-carbon bond to form 5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-CoA (EPA-CoA, 5,8,11,14,17-20:5(n-3)). Delta-5-desaturase is required for this conversion. EPA-CoA has health benefits due to its anti-inflammatory actions. It is a precursor for the anti-inflammatory series-3 prostaglandins (PG), the series-5 leukotrienes (LT) and the series-3 thromboxanes (TA), which are anti-atherogenic and anti-thrombogenic (Ross et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
8096621	Comparison of the metabolism of alpha-linolenic acid and its delta 6 desaturation product, stearidonic acid, in cultured NIH-3T3 cells Ells, GW, Huang, YS, Horrobin, DF, Cantrill, RC	Lipids	1993
10601301	Cloning, expression, and fatty acid regulation of the human delta-5 desaturase Cho, HP, Clarke, SD, Nakamura, M	J Biol Chem	1999