Reactome | Translocation of tetracosahexaenoyl-CoA to peroxisomes

Translocation of tetracosahexaenoyl-CoA to peroxisomes

Stable Identifier

R-HSA-2046087

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane, peroxisomal membrane, peroxisomal matrix

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Translocation of tetracosahexaenoyl-CoA to peroxisomes

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The 24-carbon tetracosahexaenoyl-CoA (6,9,12,15,18,21-24:6(n-3) is transported to peroxisomes to undergo a putative single cycle of peroxisomal beta-oxidation, producing Docosahexaenoic Acid (DHA) (Sprecher 2002, Luthria et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
11500517	Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis Su, HM, Moser, AB, Moser, HW, Watkins, PA	J Biol Chem	2001
12897190	Studies on the metabolic fate of n-3 polyunsaturated fatty acids Ferdinandusse, S, Denis, S, Dacremont, G, Wanders, RJ	J Lipid Res	2003
8656081	Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA	J Lipid Res	1995