Translocation of tetracosahexaenoyl-CoA to peroxisomes

Stable Identifier
Reaction [transition]
Homo sapiens
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The 24-carbon tetracosahexaenoyl-CoA (6,9,12,15,18,21-24:6(n-3) is transported to peroxisomes to undergo a putative single cycle of peroxisomal beta-oxidation, producing Docosahexaenoic Acid (DHA) (Sprecher 2002, Luthria et al. 1996).

Literature References
PubMed ID Title Journal Year
11500517 Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis

Su, HM, Moser, AB, Moser, HW, Watkins, PA

J Biol Chem 2001
12897190 Studies on the metabolic fate of n-3 polyunsaturated fatty acids

Ferdinandusse, S, Denis, S, Dacremont, G, Wanders, RJ

J Lipid Res 2003
8656081 Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Moore, SA, Hurt, E, Yoder, E, Sprecher, H, Spector, AA

J Lipid Res 1995
Catalyst Activity

long-chain fatty acid transporter activity of ABCD1 [peroxisomal membrane]

Orthologous Events
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