PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992, Chantry et al. 1997). Experiments in mice indicate that PI3K associated with BCAP is partly responsible for the activity (Aiba et al. 2008). (PI3K associated with CD19 is also partly responsible (Aiba et al. 2008).)
Chantry, D, Vojtek, A, Kashishian, A, Holtzman, DA, Wood, C, Gray, PW, Cooper, JA, Hoekstra, MF
Aiba, Y, Kameyama, M, Yamazaki, T, Tedder, TF, Kurosaki, T
Gold, MR, Chan, VW, Turck, CW, DeFranco, AL
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