Reactome | BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

Stable Identifier

R-HSA-2045911

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

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BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

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PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992, Chantry et al. 1997). Experiments in mice indicate that PI3K associated with BCAP is partly responsible for the activity (Aiba et al. 2008). (PI3K associated with CD19 is also partly responsible (Aiba et al. 2008).)

Literature References

PubMed ID	Title	Journal	Year
9235916	p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes Chantry, D, Vojtek, A, Kashishian, A, Holtzman, DA, Wood, C, Gray, PW, Cooper, JA, Hoekstra, MF	J Biol Chem	1997
18025150	Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase Aiba, Y, Kameyama, M, Yamazaki, T, Tedder, TF, Kurosaki, T	Blood	2008
1372019	Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes Gold, MR, Chan, VW, Turck, CW, DeFranco, AL	J Immunol	1992