CyP60 chaperones Basigin

Stable Identifier
R-HSA-204500
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
ReviewStatus
5/5
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CyP60 chaperones Basigin
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Basigin serves as a signaling receptor for extracellular cyclophilins. Its been reported that cyclophilin 60 (Cyp60), a distinct member of the cyclophilin family is involved in the regulation of intracellular transport of basigin. The mechanism of this activity involves interaction of Cyp60 with the proline-containing region within or adjacent to the predicted transmembrane domain basigin. Cyp60 is co-localized with basigin at the plasma membrane suggesting that Cyp60 may function as a chaperone escorting basigin through the secretory pathway.
Literature References
PubMed ID Title Journal Year
15946952 Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60

Pushkarsky, T, Yurchenko, V, Vanpouille, C, Brichacek, B, Vaisman, I, Hatakeyama, S, Nakayama, KI, Sherry, B, Bukrinsky, MI

J Biol Chem 2005
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Orthologous Events
CyP60 chaperones Basigin (Caenorhabditis elegans)
CyP60 chaperones Basigin (Danio rerio)
CyP60 chaperones Basigin (Drosophila melanogaster)
CyP60 chaperones Basigin (Gallus gallus)
CyP60 chaperones Basigin (Mus musculus)
CyP60 chaperones Basigin (Rattus norvegicus)
CyP60 chaperones Basigin (Xenopus tropicalis)
Authored
de Bono, B  (2008-02-26)
Garapati, P V  (2008-02-26)
Reviewed
Trowsdale, J  (2008-02-26)
Created
de Bono, B  (2007-11-28)
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