CyP60 chaperones Basigin

Stable Identifier
R-HSA-204500
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
ReviewStatus
5/5
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CyP60 chaperones Basigin
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Basigin serves as a signaling receptor for extracellular cyclophilins. Its been reported that cyclophilin 60 (Cyp60), a distinct member of the cyclophilin family is involved in the regulation of intracellular transport of basigin. The mechanism of this activity involves interaction of Cyp60 with the proline-containing region within or adjacent to the predicted transmembrane domain basigin. Cyp60 is co-localized with basigin at the plasma membrane suggesting that Cyp60 may function as a chaperone escorting basigin through the secretory pathway.
Literature References
PubMed ID Title Journal Year
15946952 Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60

Hatakeyama, S, Vanpouille, C, Sherry, B, Nakayama, KI, Yurchenko, V, Brichacek, B, Vaisman, I, Pushkarsky, T, Bukrinsky, MI

J Biol Chem 2005
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Orthologous Events
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CyP60 chaperones Basigin (Gallus gallus)
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CyP60 chaperones Basigin (Xenopus tropicalis)
Authored
Garapati, P V  (2008-02-26)
de Bono, B  (2008-02-26)
Reviewed
Trowsdale, J  (2008-02-26)
Created
de Bono, B  (2007-11-28)
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