Basigin serves as a signaling receptor for extracellular cyclophilins. Its been reported that cyclophilin 60 (Cyp60), a distinct member of the cyclophilin family is involved in the regulation of intracellular transport of basigin. The mechanism of this activity involves interaction of Cyp60 with the proline-containing region within or adjacent to the predicted transmembrane domain basigin. Cyp60 is co-localized with basigin at the plasma membrane suggesting that Cyp60 may function as a chaperone escorting basigin through the secretory pathway.
Hatakeyama, S, Vanpouille, C, Sherry, B, Nakayama, KI, Yurchenko, V, Brichacek, B, Vaisman, I, Pushkarsky, T, Bukrinsky, MI
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