Basigin binds CyPA

Stable Identifier
R-HSA-204485
Type
Reaction
Species
Homo sapiens
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Cyclophilin A (CyPA)1 is an intracellular protein belonging to the immunophilin family and is recognized as the major target for the potent immunosuppressive drug cyclosporin A. CD147 is the natural cell surface receptor for CyPA. It is demonstrated that CD147 is an essential component in the CyPA-initiated signaling cascade that culminates in ERK activation.

Literature References
PubMed ID Title Journal Year
11943775 Active site residues of cyclophilin A are crucial for its signaling activity via CD147

Gallay, P, Toole, B, Bukrinsky, M, Hung, HC, O'Connor, M, Sherry, B, Yurchenko, V, Franchin, G, Hao, T, Dai, WW, Guo, H, Zybarth, G

J Biol Chem 2002
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