Basigin binds CyPA

Stable Identifier
R-HSA-204485
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cyclophilin A (CyPA)1 is an intracellular protein belonging to the immunophilin family and is recognized as the major target for the potent immunosuppressive drug cyclosporin A. CD147 is the natural cell surface receptor for CyPA. It is demonstrated that CD147 is an essential component in the CyPA-initiated signaling cascade that culminates in ERK activation.
Literature References
PubMed ID Title Journal Year
11943775 Active site residues of cyclophilin A are crucial for its signaling activity via CD147

Gallay, P, Toole, B, Bukrinsky, M, Hung, HC, O'Connor, M, Sherry, B, Yurchenko, V, Franchin, G, Hao, T, Dai, WW, Guo, H, Zybarth, G

J Biol Chem 2002
Participants
Participates
This event is regulated
Positively by
Orthologous Events
Authored
Reviewed
Created
Cite Us!