Reactome | Basigin binds MCT1, MCT3 and MCT4

Basigin binds MCT1, MCT3 and MCT4

Stable Identifier

R-HSA-204392

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

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Proton-coupled monocarboxylate transporters (MCT) MCT1, MCT3, and MCT4 form heterodimeric complexes with the cell surface glycoprotein CD147 and exhibit tissue-specific polarized distributions that are essential for maintaining lactate and pH homeostasis.

Literature References

PubMed ID	Title	Journal	Year
16260747	Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia Hu, J, Rodriguez-Boulan, E, Bok, D, Philp, N, Deora, AA	Proc Natl Acad Sci U S A	2005
10921872	CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression Halestrap, AP, Wilson, MC, Kirk, P, Barclay, AN, Heddle, C, Brown, MH	EMBO J	2000
11719518	Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ Meredith, D, Halestrap, AP, Wilson, MC	J Biol Chem	2002