Reactome | SEC24D [endoplasmic reticulum membrane]

SEC24D [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-204004

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Protein transport protein Sec24D, S24D_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Capturing cargo and formation of prebudding complex (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Budding of COPII coated vesicle (Homo sapiens)
        
        COPII vesicle with MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Capturing cargo and formation of prebudding complex (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Coat Assembly (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)
        
        COPII vesicle with MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
  - MHC class II antigen presentation (Homo sapiens)
    - Formation of COPII vesicle (Homo sapiens)
      - COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
    - Fusion of COPII vesicle with Golgi complex (Homo sapiens)
      - COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
      - SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)
        
        SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Loss of SAR1B GTPase (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Loss of SAR1B GTPase (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
    - Cargo concentration in the ER (Homo sapiens)
      - Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94855 SEC24D

Gene Names

SEC24D, KIAA0755

Chain

chain:1-1032

Reference Genes

BioGPS Gene:9871 SEC24D

COSMIC (genes):SEC24D SEC24D

CTD Gene:9871 SEC24D

dbSNP Gene:9871 SEC24D

ENSEMBL:ENSG00000150961 SEC24D

HGNC:10706 SEC24D

KEGG:hsa:9871 SEC24D

Monarch:9871 SEC24D

NCBI Gene:9871 SEC24D

OMIM:607186 SEC24D

UCSC:O94855 SEC24D

Reference Transcript

Participates

as a member of

SEC24 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

p-SEC24D [cytosol]

SEC24D [ER to Golgi transport vesicle membrane]

SEC24D [cytosol]

Inferred To

Sec24d [endoplasmic reticulum membrane] (Mus musculus)

Sec24d [endoplasmic reticulum membrane] (Rattus norvegicus)

sec24d [endoplasmic reticulum membrane] (Xenopus tropicalis)

Sec24CD [endoplasmic reticulum membrane] (Drosophila melanogaster)

SFB3 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

sec-24.1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

SEC24D [endoplasmic reticulum membrane] (Bos taurus)

SEC24D [endoplasmic reticulum membrane] (Canis familiaris)

SEC24D [endoplasmic reticulum membrane] (Gallus gallus)

SEC24D [endoplasmic reticulum membrane] (Plasmodium falciparum)

SEC24D [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

SEC24D [endoplasmic reticulum membrane] (Sus scrofa)

sec24l [endoplasmic reticulum membrane] (Dictyostelium discoideum)

Cross References

ENSEMBL

ENST00000280551, ENSP00000280551, ENSG00000150961

OpenTargets

ENSG00000150961

GeneCards

SEC24D

HPA

ENSG00000150961-SEC24D

PRO

O94855

Pharos - Targets

O94855

GlyGen

O94855

Orphanet

SEC24D

PDB

5KYU, 3EG9, 5KYW, 5KYX, 3EFO, 5KYY

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.688	5

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