Reactome | SEC24D [endoplasmic reticulum membrane]

SEC24D

Stable Identifier

R-HSA-204004

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Protein transport protein Sec24D, S24D_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Budding of COPII coated vesicle (Homo sapiens)
        
        COPII vesicle with MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Capturing cargo and formation of prebudding complex (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Coat Assembly (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)
        
        COPII vesicle with MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
  - MHC class II antigen presentation (Homo sapiens)
    - Formation of COPII vesicle (Homo sapiens)
      - COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
    - Fusion of COPII vesicle with Golgi complex (Homo sapiens)
      - COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
      - SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)
        
        SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Loss of SAR1B GTPase (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Loss of SAR1B GTPase (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)
    - Cargo concentration in the ER (Homo sapiens)
      - Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24D [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94855 SEC24D

Gene Names

SEC24D, KIAA0755

Chain

chain:1-1032

Reference Genes

BioGPS Gene:9871 SEC24D

COSMIC (genes):SEC24D SEC24D

CTD Gene:9871 SEC24D

dbSNP Gene:9871 SEC24D

ENSEMBL:ENSG00000150961 SEC24D

HGNC:10706 SEC24D

KEGG Gene (Homo sapiens):hsa:9871 SEC24D

Monarch:9871 SEC24D

NCBI Gene:9871 SEC24D

OMIM:607186 SEC24D

UCSC:O94855 SEC24D

Reference Transcript

Other Identifiers

0005130593

11717319_a_at

11746083_a_at

16979256

202375_at

2783317

2783318

2783325

2783328

2783329

2783336

2783338

2783340

2783341

2783343

2783344

2783345

2783347

2783349

2783352

2783355

2783356

2783364

2783365

2783367

2783368

2783369

2783375

2783380

2783383

2783384

2783385

2783386

32770_at

3EFO

3EG9

41626

53486

5KYU

5KYW

5KYX

5KYY

69085_s_at

8102482

9871

A_23_P159382

AAD28756

AAH35761

AB018298

AF130464

BAA34475

BC035761

CCDS3710

CH471229

D6RAE2

D6RBM1

D6RGJ5

E9PC44

E9PDM8

E9PG84

EAW73656

ENSG00000150961

ENSP00000280551

ENST00000280551

EntrezGene:9871

g7662658_3p_at

GE53464

GO:0000139

GO:0000149

GO:0001701

GO:0002376

GO:0002474

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006810

GO:0006886

GO:0006888

GO:0008150

GO:0008270

GO:0009790

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0019886

GO:0022607

GO:0030127

GO:0031410

GO:0032991

GO:0043167

GO:0043226

GO:0046872

GO:0048208

GO:0048856

GO:0061024

GO:0065003

GO:0090110

HGNC:10706

HPA041626

HPA053486

ILMN_1656386

IPR006895

IPR006896

IPR006900

IPR007123

IPR012990

IPR029006

IPR036175

IPR036180

IPR036465

MIM:607186

MIM:616294

NM_001318066

NM_014822

NP_001304995

NP_055637

PF00626

PF04810

PF04811

PF04815

PF08033

PH_hs_0024795

SEC24D

SEC24D-201

TC04001496.hg

uc003ici.5

UPI00001AEA4F

XM_005263379

XP_005263436

Participant Of

hasMember

SEC24 [endoplasmic reticulum membrane]

Other forms of this molecule

p-SEC24D [cytosol]

SEC24D [ER to Golgi transport vesicle membrane]

SEC24D [cytosol]

Inferred To

SEC24D [endoplasmic reticulum membrane] (Arabidopsis thaliana)

SEC24D [endoplasmic reticulum membrane] (Bos taurus)

SEC24D [endoplasmic reticulum membrane] (Caenorhabditis elegans)

SEC24D [endoplasmic reticulum membrane] (Canis familiaris)

SEC24D [endoplasmic reticulum membrane] (Danio rerio)

SEC24D [endoplasmic reticulum membrane] (Dictyostelium discoideum)

SEC24D [endoplasmic reticulum membrane] (Drosophila melanogaster)

SEC24D [endoplasmic reticulum membrane] (Gallus gallus)

SEC24D [endoplasmic reticulum membrane] (Mus musculus)

SEC24D [endoplasmic reticulum membrane] (Oryza sativa)

SEC24D [endoplasmic reticulum membrane] (Plasmodium falciparum)

SEC24D [endoplasmic reticulum membrane] (Rattus norvegicus)

SEC24D [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

SEC24D [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

SEC24D [endoplasmic reticulum membrane] (Sus scrofa)

SEC24D [endoplasmic reticulum membrane] (Taeniopygia guttata)

SEC24D [endoplasmic reticulum membrane] (Xenopus tropicalis)

Homologues of SEC24D [endoplasmic reticulum membrane] (Arabidopsis thaliana)

Homologues of SEC24D [endoplasmic reticulum membrane] (Dictyostelium discoideum)

Homologues of SEC24D [endoplasmic reticulum membrane] (Drosophila melanogaster)

Homologues of SEC24D [endoplasmic reticulum membrane] (Mus musculus)

Homologues of SEC24D [endoplasmic reticulum membrane] (Oryza sativa)

Homologues of SEC24D [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of SEC24D [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

XP_005263436.1, NP_001304995.1, NP_055637.2

GeneCards

O94855

PRO

O94855

Orphanet

23212

PDB

5KYX, 5KYU, 5KYY, 3EG9, 3EFO, 5KYW